A venetoclax and azacitidine bridge-to-transplant strategy for NPM1-mutated acute myeloid leukaemia in molecular failure

NPM1-mutated acute myeloid leukaemia (NPM1mut AML) represents a mostly favourable/intermediate risk disease that benefits from allogeneic haematopoietic stem cell transplantation (HSCT) in case of measurable residual disease (MRD) relapse or persistence after induction chemotherapy. Although the negative prognostic role of pre-HSCT MRD is established, no recommendations are available for the management of peri-transplant molecular failure (MF). Based on the efficacy data of venetoclax (VEN)-b...

Enabling true decision making through personalized informed consent: omne ignotum pro terribili

Factors influencing the recruitment of Gongolaria barbata (Fucales) in the Conero Riviera: implications for conservation and restoration

Gongolaria barbata is a brown macroalga in the Fucales. This species is widely distributed in the Mediterranean Sea, where it can form dense canopies on hard substrata in the infralittoral zone. Gongolaria barbata plays a pivotal role as habitat former and ecosystem engineer, but in recent decades its distribution has declined, mostly due to anthropogenic stressors. Protection under international conventions and several active restoration projects, in the majority of cases, failed to achieve ...

Biliary Granulomatous Peritoneal Reaction as Consequence of Cholecystectomy: Case Report and Literature Review

Bileor gallstone spillage during laparoscopic cholecystectomy occurs in 13 to 40% of cases of surgical dissection and extraction of a very inflamed gallbladder with friable or gangrenous walls. We present a case of a patient who developed a biliary granulomatous peritoneal reaction as consequence of cholecystectomy for acute-on-chronic cholecystitis. Our patient, after about 2 years from the surgery, in the follow-up imaging studies, showed multiple nodules disseminated in the peritoneal cavi...