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Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy

Background: Translational studies have provided evidence that targeted therapies and chemotherapy might induce a status of adaptive mutability with an increase in the tumor mutational load. Patients and methods: We conducted an analysis of pathogenic variants (PVs) detected by liquid biopsy (LBx)-based comprehensive genomic profiling in patients with chemo-refractory microsatellite-stable metastatic colorectal cancer (mCRC) pretreated with anti-epidermal growth factor receptor (EGFR) within t...

The role of colposcopy in HPV vaccination era

Colposcopy has traditionally played a crucial role in the assessment and management of abnormal cervical cytology and human papillomavirus (HPV)-related lesions. However, with the reduction in high-risk (HR) HPV types due to vaccination, the role of colposcopy in the HPV vaccination era is being questioned. The aim of this narrative review was to highlight the latest evidence from the world of HPV vaccination and the future role of colposcopy in the HPV vaccination era. PubMed, MEDLINE, Scopu...

The role of professional oral hygiene in enhancing outcomes of maxillofacial trauma surgery

Background: The oral cavity poses challenges in surgical interventions due to its microbial flora. Maxillofacial trauma surgeries are vulnerable to infections, complicating recovery. Traditional methods, including antibiotic prophylaxis, have limitations, highlighting the need for complementary strategies. Objective: This study evaluated the impact of professional oral hygiene protocol on infection rates, mucosal health, and pain levels in maxillofacial trauma patients. Material and methods: ...

Harmonic and superharmonic wave propagation in 2D mechanical metamaterials with inertia amplification

An original parametric lattice model is proposed to investigate harmonic and superharmonic planar waves propagating in a two-dimensional mechanical metamaterial, whose periodic microstructure is characterized by local linkage mechanisms for pantographic inertia amplification. The free undamped dynamics in the metamaterial plane is governed by differential difference equations of motion, featuring geometric nonlinearities of both elastic and inertial nature. Within the weakly nonlinear oscilla...

The effect of healthcare disruptions during the COVID‐19 pandemic on colposcopy services and practice: A systematic review and meta‐analysis

Introduction: The healthcare reorganization during the COVID-19 pandemic affected colposcopy services and cervical cancer prevention, particularly in those countries where healthcare systems were already under-resourced. This review aimed to quantify the reduction in colposcopy services across countries during the COVID-19 pandemic and to determine whether the data source per study and cervical cancer screening coverage per country influenced the extent of these reductions. Material and Metho...

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