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Targeting paraoxonase-2 overcomes chemoresistance in triple-negative breast cancer cells by inducing extensive metabolic and molecular remodeling

Triple-negative breast cancer (TNBC) remains an aggressive malignancy characterized by limited therapeutic options and a high propensity for chemoresistance. Increasing evidence indicates that metabolic and redoxregulating enzymes are pivotal in driving TNBC progression and survival under pharmacological stress. In this study, we investigated whether paraoxonase-2 (PON2), a key modulator of oxidative stress and mitochondrial function, may represent a potential target to enhance the efficacy o...

Quantifying old-growth forest attributes in anthropogenic landscapes: A methodological approach based on structural indicators

Forests exhibiting old-growth (OG) attributes represent only a small fraction of global forest cover, yet they harbor disproportionately high ecological value in terms of ecosystem functions, structural complexity, and biodiversity. Identifying and quantifying such forests is particularly challenging in anthropogenically disturbed landscapes, where they can serve as reference models for guiding managed forests toward more resilient and ecologically valuable conditions. We developed a multi-le...

Gamma-distributed delays in the prisoner’s dilemma with defection penalty: Stability hierarchy of memory kernels

A penalty on mutual defection creates an interior coexistence equilibrium in the prisoner's dilemma, but payoff information received with delay can destabilise that equilibrium. We examine how this outcome depends on the temporal distribution of memory. Replacing the discrete delay of Wang and Meng [1] with gamma-distributed payoff feedback, we use the linear chain trick to obtain finite-dimensional ODE representations. Exponentially fading (weak) memory makes the coexistence equilibrium loca...

Expected foreign military intervention and demand for state-building: Evidence from Mali

We study how the announcement of a foreign military intervention, which improves expectations about the state’s future functioning, can raise citizens’ willingness to participate in state-building processes. We analyze the impact of the 2012 United Nations Security Council resolution that authorized intervention in Mali to reunify the country and restore democracy during a profound institutional crisis on individuals’ attitudes toward the state. By exploiting the randomness of the foreign int...

Age-related reduction in D-dimer cut-off specificity: Diagnostic relevance in geriatric patients

Introduction: D-dimer testing is widely used to exclude pulmonary embolism (PE), but its specificity declines sharply with age. Evidence in very old adults is limited, as most validation studies include few patients aged ≥80 years. This study aimed to identify and validate a clinically appropriate D-dimer threshold for geriatric patients. Methods: Two large cohorts of adults evaluated for suspected PE in a Geriatric Emergency Department were included. The derivation cohort included 1617 patie...

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