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Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: An observational study

Background: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of COPD, with few cardiologic adverse effects. We evaluated the safety and efficacy of this therapy in patients with history of HF. Methods: We enrolled 56 patients with a history of HF (New York Heart Associa...

High frequency of CD95+/CD45RA− regulatory T cells defines an immunosuppressive profile associated with MDS progression

Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow (BM) of MDS patients and to explore their clinical significance. Using mass cytometry and an unbiased multidimensional analytical approach, we first confirmed the presence in MDS BM of two Treg su...

First Results Using Digital Image Correlation for Deformation Field Measurements in Laboratory Tests on Textile Reinforced Mortar (TRM)-strengthened Masonry Panels

The Digital Image Correlation (DIC) technique is a non-contact, full-field optical method and a non-destructive evaluation approach that enables the measure-ment of displacements and strain fields across an entire surface during experimen-tal tests. This technique provides high-resolution data, enabling the measurement of global strain, the detection of localized strain concentrations and crack initiation, and monitoring the evolution o...

Peering into the twilight: a systematic review on visual-based investigation of worldwide mesophotic ecosystems

Mesophotic ecosystems host high biodiversity and support a vast variety of habitats. Owing to climate change, there is a growing interest in the study of mesophotic assemblages as a possible pocket of biodiversity for species. However, due to logistic constraints, these habitats have been historically less investigated and mostly neglected in conservation planning. Thus, it is difficult to gain a global overview of the state of the art, especially with regards to sampling methodology. Here, w...

Patrimoni contesi e terre di confine: il confine come lente per leggere la storia urbana

Historically, cities have been shaped by various forms of boundary lines: some physical and impenetrable, such as defensive city walls; others non-physical yet equally powerful, such as those that separated the city from the countryside. The concept of the border has evolved over time, expanding beyond its initial geographical conception to encompass social, political, cultural, and psychological dimensions of territory – a condition most evident in borderlands marked by conflict. These trans...

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