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Gold nanoparticles decorated with monosaccharides and sulfated ligands as potential modulators of the lysosomal enzyme N-acetylgalactosamine-6-sulfatase (GALNS)

: N-Acetylgalactosamine-6-sulfatase (GALNS) is an enzyme whose deficiency is related to the lysosomal storage disease Morquio A. For the development of effective therapeutic approaches against this disease, the design of suitable enzyme enhancers (i.e. pharmacological chaperones) is fundamental. The natural substrates of GALNS are the glycosaminoglycans keratan sulfate and chondroitin 6-sulfate, which mainly display repeating units of sulfated carbohydrates. With a biomimetic approach, gold n...

Characterization of aged bitumen recovered from in-situ polymer-modified HMA and WMA using advanced technologies

The growing attention of public opinion towards the environment has prompted, in the last decades, to find eco- sustainable and economic alternatives to the traditional productions of hot-mix asphalt (HMA). Under these auspices, the use of warm mix asphalt (WMA) technology applied to mixtures containing reclaimed asphalt (RA) has grown, also due to the well-proven advantages in terms of plant odor emissions and improved working conditions. In addition, it is now known that the mechanical ...

Interlayer bonding properties of warm recycled asphalt pavements

The need for sustainable road infrastructures has led to great interest in Warm Mix Asphalt (WMA) technologies, which allow the production, lay-down and compaction of asphalt mixtures at reduced temperatures, about 40 degrees C lower than traditional Hot Mix Asphalt (HMA). The use of WMA ensures lower emissions and is also beneficial in the recycling of Reclaimed Asphalt (RA) deriving from the milling of end-of-life pavements. One of the main concerns regarding WMA is the possible poor adhesi...

An emotion-aware search engine for multimedia content based on deep learning algorithms

Nowadays, large amounts of unstructured data are available online. Such data often contain users’ emotions and feelings about a variety of topics but their retrieval and selection on the basis of an emotional perspective are usually unfeasible through traditional search engines, which only rank web content according to its relevance with respect to a given search keyword. For this reason, in the present work we introduce the architecture of a novel emotion-aware search engine that can return ...

Understanding the stumbling blocks of Italian higher education system: A process mining approach

Nowadays universities strive to continuously enhance their educational programs to improve both the quality and quantity of their graduates. This is a sensitive problem, especially for Italian universities where only 30% of the students enrolled at the university succeed in graduating within a year after the normal duration of the study plan. Over the last few years, the Italian Ministry of University and Education has introduced several indicators to assess students’ careers and help univers...

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Prodotti recenti

Gold nanoparticles decorated with monosaccharides and sulfated ligands as potential modulators of the lysosomal enzyme N-acetylgalactosamine-6-sulfatase (GALNS)

Characterization of aged bitumen recovered from in-situ polymer-modified HMA and WMA using advanced technologies

Interlayer bonding properties of warm recycled asphalt pavements

An emotion-aware search engine for multimedia content based on deep learning algorithms

Understanding the stumbling blocks of Italian higher education system: A process mining approach

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