Very few studies assessed cholangiocarcinoma clinical characteristics.To evaluate the clinical characteristics of intra-hepatic (IH) and extra-hepatic (EH)-CCA.We performed a national survey based on a questionnaire.218 cholangiocarcinomas were observed (47\% EH-CCA, 53\% IH-CCA) with an age at the diagnosis higher for EH-CCA. Coexistence of cirrhosis or viral cirrhosis was more frequent in IH-CCA than EH-CCA. An incidental asymptomatic presentation occurred in 28\% of IH-CCA vs 4\% EH-CCA whilst, 74\% EH-CCA vs 28\% IH-CCA presented with jaundice. 91\% of IH-CCA presented as a single intra-hepatic mass, whilst 50\% of EH-CCA was peri-hilar. In the diagnostic work-up, 70\% of all cholangiocarcinoma cases received at least 3 different imaging procedures. Tissue-proven diagnosis was obtained in 80\% cholangiocarcinoma. Open surgery with curative intent was performed in 45\% of IH-CCA and 29\% EH-CCA. 18\% IH-CCA vs 4\% EH-CCA did not received treatment.In Italy IH-CCA is managed as frequently as EH-CCA. In comparison to EH-CCA, IH-CCA occurs at younger age and is more frequently associated with cirrhosis and with an incidental asymptomatic presentation. In contrast, most EH-CCAs are jaundiced at the diagnosis. Cholangiocarcinoma diagnostic management is cost- and time-consuming with curative surgical treatment applicable more frequently in IH-CCA.
Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease / D., Alvaro; M. C., Bragazzi; Benedetti, Antonio; L., Fabris; G., Fava; P., Invernizzi; Marzioni, Marco; G., Nuzzo; M., Strazzabosco; T., Stroffolini; A. I. S. F., “Cholangiocarcinoma” committee. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 43:(2011), pp. 60-65. [10.1016/j.dld.2010.05.002]
Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease.
BENEDETTI, Antonio;MARZIONI, MARCO;
2011-01-01
Abstract
Very few studies assessed cholangiocarcinoma clinical characteristics.To evaluate the clinical characteristics of intra-hepatic (IH) and extra-hepatic (EH)-CCA.We performed a national survey based on a questionnaire.218 cholangiocarcinomas were observed (47\% EH-CCA, 53\% IH-CCA) with an age at the diagnosis higher for EH-CCA. Coexistence of cirrhosis or viral cirrhosis was more frequent in IH-CCA than EH-CCA. An incidental asymptomatic presentation occurred in 28\% of IH-CCA vs 4\% EH-CCA whilst, 74\% EH-CCA vs 28\% IH-CCA presented with jaundice. 91\% of IH-CCA presented as a single intra-hepatic mass, whilst 50\% of EH-CCA was peri-hilar. In the diagnostic work-up, 70\% of all cholangiocarcinoma cases received at least 3 different imaging procedures. Tissue-proven diagnosis was obtained in 80\% cholangiocarcinoma. Open surgery with curative intent was performed in 45\% of IH-CCA and 29\% EH-CCA. 18\% IH-CCA vs 4\% EH-CCA did not received treatment.In Italy IH-CCA is managed as frequently as EH-CCA. In comparison to EH-CCA, IH-CCA occurs at younger age and is more frequently associated with cirrhosis and with an incidental asymptomatic presentation. In contrast, most EH-CCAs are jaundiced at the diagnosis. Cholangiocarcinoma diagnostic management is cost- and time-consuming with curative surgical treatment applicable more frequently in IH-CCA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.