Objective: There is growing interest in the early identification of patients with axial psoriatic arthritis (axPsA). We aimed to evaluate whether a dermatology-based screening strategy could help to identify axPsA patients. Methods: The dermatologist-centered screening (DCS) questionnaire was administrated by Dermatologists to consecutive patients fulfilling the inclusion criteria (1. age ≥ 18 years and 2. clinical diagnosis of psoriasis made by a dermatologist) to identify patients eligible (affirmative answers 1-3c of the DCS) for rheumatological evaluation. Clinical, laboratory, genetic, and imaging data were collected from all referred patients. Results: Among the 365 patients screened, 265 fulfilled the inclusion criteria and 124/265 (46.8%) were eligible for rheumatological referral. Diagnosis of axPsA, with or without peripheral PsA (pPsA), was made in 36/124 (29.0%) patients; pPsA without axial involvement was found in 21/124 (16.9%) patients. Back pain at screening was recorded in 174 (66%) patients, with 158 (60%) reporting a back pain duration longer than 3 months, and 140 (53%) reporting back pain onset before the age of 45. Active inflammatory and/or structural post-inflammatory changes in the sacroiliac joints and/or spine were observed in all axPsA patients.Patients with PsA showed a numerically longer duration of back pain and higher CRP levels in comparison with patients with Pso without PsA. Conclusion: The DCS tool proved to be a valuable screening strategy for detecting and characterizing patients with axPsA in a real-life cohort of psoriasis patients in a dermatological setting and helped to identify a substantial number of patients affected by undiagnosed pPsA.
The ATTRACT study: screening for the early identification of axial psoriatic arthritis in a cohort of Italian psoriatic patients / Gentiloni, Michele Maria Luchetti; Paci, Valentino; Cimaroli, Ilaria; Agostinelli, Alice; Giannoni, Melania; Campanati, Anna; Diotallevi, Federico; Carotti, Marina; Sessa, Francesco; Sordillo, Raffaella; Macchini, Cristina; Fiorini, Federico; Massaccesi, Leonardo; Ciferri, Monia; Gigli, Marco; Marconi, Valentina; Perini, Lucia; Marani, Andrea; Giovagnoni, Andrea; Polonara, Gabriele; Offidani, Anna Maria; Benfaremo, Devis; Proft, Fabian; Poddubbny, Denis; Moroncini, Gianluca. - In: RHEUMATOLOGY. - ISSN 1462-0324. - (2023). [10.1093/rheumatology/kead566]