Primary Sclerosing Cholangitis(PSC) is a chronic liver disease characterized by inflammation of the biliary epithelia progressively leading to fibrosis and biliary strictures formation and in the advanced disease to liver cirrhosis and cholangiocarcinoma occurrence. To date, PSC eziology is not fully understood leading to a lack in effective therapies able to reduce disease progression. The present review aims to discuss the current concepts about PSC pathogenesis and provides an updating of the therapeutical approaches against such chronic biliary disease.
Current targets for Primary Sclerosing cholangitis / Pierantonelli, Irene; Benedetti, Antonio; Marzioni, Marco. - In: CURRENT DRUG TARGETS. - ISSN 1873-5592. - (2016). [10.2174/1389450117666160112114152]
Current targets for Primary Sclerosing cholangitis
PIERANTONELLI, IRENE;BENEDETTI, Antonio;MARZIONI, MARCO
2016-01-01
Abstract
Primary Sclerosing Cholangitis(PSC) is a chronic liver disease characterized by inflammation of the biliary epithelia progressively leading to fibrosis and biliary strictures formation and in the advanced disease to liver cirrhosis and cholangiocarcinoma occurrence. To date, PSC eziology is not fully understood leading to a lack in effective therapies able to reduce disease progression. The present review aims to discuss the current concepts about PSC pathogenesis and provides an updating of the therapeutical approaches against such chronic biliary disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
