IRIS
SORCI, Leonardo
 Distribuzione geografica
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Continente #
NA - Nord America 2.718
EU - Europa 1.947
AS - Asia 680
SA - Sud America 102
AF - Africa 32
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 5.487
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Nazione #
US - Stati Uniti d'America 2.705
IT - Italia 559
DE - Germania 334
UA - Ucraina 259
SG - Singapore 258
RU - Federazione Russa 180
IE - Irlanda 173
SE - Svezia 138
CN - Cina 129
HK - Hong Kong 115
DK - Danimarca 93
BR - Brasile 92
TR - Turchia 79
FI - Finlandia 56
KR - Corea 50
FR - Francia 49
GB - Regno Unito 49
AT - Austria 18
CI - Costa d'Avorio 16
NL - Olanda 14
BE - Belgio 13
IN - India 12
VN - Vietnam 11
PH - Filippine 8
CA - Canada 6
EG - Egitto 6
EU - Europa 4
PT - Portogallo 4
UZ - Uzbekistan 4
AE - Emirati Arabi Uniti 3
AR - Argentina 3
JP - Giappone 3
MA - Marocco 3
MX - Messico 3
RO - Romania 3
ZA - Sudafrica 3
AU - Australia 2
CL - Cile 2
CO - Colombia 2
IQ - Iraq 2
IS - Islanda 2
BY - Bielorussia 1
DZ - Algeria 1
EC - Ecuador 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
JO - Giordania 1
KE - Kenya 1
KG - Kirghizistan 1
LB - Libano 1
LK - Sri Lanka 1
NG - Nigeria 1
NI - Nicaragua 1
NZ - Nuova Zelanda 1
PA - Panama 1
PL - Polonia 1
PY - Paraguay 1
SA - Arabia Saudita 1
SV - El Salvador 1
TN - Tunisia 1
VE - Venezuela 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 5.487
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Città #
Jacksonville 277
Chandler 264
Fairfield 258
Ashburn 181
Dublin 170
Marche 162
New York 162
Wilmington 155
Boardman 139
Woodbridge 117
Hong Kong 115
Singapore 112
Houston 102
Seattle 95
Ann Arbor 91
Des Moines 86
Cambridge 80
Milan 76
Lawrence 60
Princeton 60
San Mateo 59
Centro 53
The Dalles 38
Ancona 34
Beijing 32
Moscow 29
San Diego 26
Aversa 20
Abidjan 16
Nuremberg 13
Scarlino 13
Shanghai 13
Brussels 12
Los Angeles 12
Ponte A Égola 12
Dong Ket 11
Guangzhou 11
Vienna 11
Washington 11
London 9
Turin 9
Rome 8
Ascoli Piceno 7
Wuhan 7
Camerino 6
Liberty 6
Perugia 6
São Paulo 6
Acquasanta Terme 5
Atlanta 5
Cairo 5
Norwalk 5
Pune 5
Redmond 5
Tolentino 5
Aprilia 4
Brookline 4
Jiaxing 4
Manzano 4
Turku 4
Weihai 4
Acton 3
Boston 3
Chiaravalle 3
Chicago 3
Dallas 3
Falconara Marittima 3
Frederick 3
Hamilton 3
Helsinki 3
Hyderabad 3
Izmir 3
Macerata 3
Manassas 3
Naples 3
Paris 3
Redwood City 3
Squinzano 3
Tashkent 3
Vallefoglia 3
Villacidro 3
Wuxi 3
Acquasparta 2
Acquaviva Picena 2
Agugliano 2
Aveiro 2
Brasília 2
Castelletto sopra Ticino 2
Catania 2
Cepagatti 2
Chieti 2
Chiswick 2
Cingoli 2
Council Bluffs 2
Dubai 2
Ely 2
Forest City 2
Hounslow 2
Ipatinga 2
Jaipur 2
Totale 3.410
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Nome #
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival 358
THE DIFFERENTIAL BIOCHEMICAL PROPERTIES OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ISOZYMES ENABLE TO DETERMINE THEIR RELATIVE EXPRESSION LEVELS 245
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi 131
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues 119
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD) 110
Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4 109
Biological Activities of the Essential Oil from Erigeron floribundus 107
Identification of a novel human nicotinamide mononucleotide adenylyltransferase 106
Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases 102
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells 101
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 101
Novel assay identifies Nicotinamide riboside, the form of vitamin B3 that boosts metabolism, as a constituent of milk at levels comparable to Niacin 100
Synthesis and degradation of adenosine 5’-tetraphosphate by Nicotinamide and Nicotinate phosphoribosyltransferases 99
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement 98
Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases. 94
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. 94
A circulating NAD biosynthetic enzyme is a novel modulator of inflammation 93
Genomics-driven reconstruction of Acinetobacter NAD metabolism: insights for antibacterial target selection 92
Identification of Nicotinamide Mononucleotide Deamidase of the Bacterial Pyridine Nucleotide Cycle Reveals a Novel Broadly Conserved Amidohydrolase Family 91
Bioinformatics and comparative genomics unveil an evolutionary conserved phage NAD metabolism 89
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. 88
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD 86
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation 85
Glutamine versus Ammonia Utilization in the NAD Synthetase Family. 85
Characterization of the NAD biosynthesis in Francisella tularensis 84
Exosome and microvesicle miRNAs belong to the pro-inflammatory secretome of senescent endothelial cells 84
NAD biosynthesis enzymes from the bacterial world as valuable tools for vitamin B3 mononucleotides quantitation in mammals 84
Enzymology of extracellular NAD metabolism 83
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon 82
Genomics and Enzymology of NAD Biosynthesis 82
Nicotinate phosphoribosyltransferase: a novel antiinfective target? 81
Targeting NAD biosynthesis in bacterial pathogens. Structure-Based development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD 79
Evolutionary and Comparative Genome Analysis of Phage NAD Metabolic Genes 77
Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators 75
Functions of the shared N-terminus of slow wallerian degeneration (WldS) and Ube4b proteins: a sequence required for axon protection and ubiquitination 75
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY 75
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. 73
NAD homeostasis in the bacterial response to DNA/RNA damage. 72
Ammonia is the Physiological Substrate of ‘GAT-less’ Prokaryotic NAD Synthetase 71
Clonaggio ed espressione di geni da Mycobacterium tuberculosis coinvolti nella sintesi del NAD. 71
Biosintesi del NAD in Mycobacterium tubercolosis: clonaggio ed espressione dei geni nadD e nadR. 71
Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria 71
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis. 71
Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation 70
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC 69
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. 69
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. 69
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase 64
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors 64
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns 61
Quinolinate salvage and insights for targeting NAD biosynthesis in group A Streptococci. 61
A novel route of NAD synthesis is uncovered in Francisella tularensis 60
Eubacterial pyridine nucleotide cycle: identification and characterization of the 'orphan enzyme' nmn deamidase 59
Structural biology of NAD metabolism in bacteria 57
S. pyogenes is reliant on salvage of host pyridine precursors for NAD synthesis: implications for pathogenesis and antibacterial intervention 57
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer 57
NAD biosynthesis under attack 56
Regulation of host immune responses to Schistosoma mansoni by the inhibition of the parasitic NAD salvage pathway 56
Structural requirements for the interaction of the enzyme nicotinamide phosphoribosyltransferase with Toll-like receptor 4 54
The interaction between human NAMPT and NAPRT with TLR4: a focus on the molecular determinants 49
Cloning and characterization of a new human NMN adenylyltransferase. 49
Una nuova NMN adeniltrasferasi umana: clonaggio, espressione eterologa e caratterizzazione della proteina KIAA0479. 48
The enzyme NMN deamidase of the bacterial pyridine nucleotide cycle is a novel, broadly conserved amidohydrolase 47
Mycobacterium tuberculosis NAD (P) BIOSYNTHETIC ENZYMES AS NOVEL ANTIMICROBIAL DRUG TARGETS 46
Mycobacterial tuberculosis NadD, a promise for targeting latent and drug-resistant tuberculosis 42
A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase 40
Human extracellular NAMPT and NAPRT mediate the inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction 39
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis 32
Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes 30
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis 26
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design 19
Totale 5.694
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Categoria #
all - tutte 33.836
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.836
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020116 0 0 0 0 0 0 0 0 0 0 30 86
2020/20211.099 58 93 107 167 182 62 77 55 94 65 93 46
2021/2022470 23 128 6 11 14 19 24 18 35 45 58 89
2022/20231.005 77 91 64 81 67 150 2 70 239 12 110 42
2023/2024716 105 14 64 74 83 196 15 16 13 26 3 107
2024/20251.221 102 95 78 245 35 41 106 95 267 78 79 0
Totale 5.694