IRIS
SORCI, Leonardo
 Distribuzione geografica
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Continente #
NA - Nord America 5.190
AS - Asia 2.690
EU - Europa 2.621
SA - Sud America 628
Continente sconosciuto - Info sul continente non disponibili 226
AF - Africa 161
OC - Oceania 3
Totale 11.519
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Nazione #
US - Stati Uniti d'America 5.075
SG - Singapore 803
IT - Italia 731
VN - Vietnam 637
CN - Cina 579
BR - Brasile 457
DE - Germania 391
RU - Federazione Russa 350
UA - Ucraina 269
IE - Irlanda 174
FR - Francia 163
HK - Hong Kong 162
SE - Svezia 146
DK - Danimarca 95
BD - Bangladesh 93
TR - Turchia 93
GB - Regno Unito 88
FI - Finlandia 84
KR - Corea 63
VE - Venezuela 55
IQ - Iraq 47
MX - Messico 44
AR - Argentina 41
IN - India 40
CA - Canada 39
SN - Senegal 38
CI - Costa d'Avorio 37
NL - Olanda 27
ZA - Sudafrica 27
EC - Ecuador 25
PK - Pakistan 24
PL - Polonia 24
AT - Austria 23
CO - Colombia 20
ID - Indonesia 19
JP - Giappone 17
PH - Filippine 17
UZ - Uzbekistan 16
BE - Belgio 13
DZ - Algeria 13
MA - Marocco 13
AE - Emirati Arabi Uniti 10
ES - Italia 10
PY - Paraguay 9
EG - Egitto 8
PE - Perù 8
TH - Thailandia 8
CL - Cile 7
JO - Giordania 7
SA - Arabia Saudita 7
SV - El Salvador 7
PT - Portogallo 6
TN - Tunisia 6
AZ - Azerbaigian 5
HN - Honduras 5
KE - Kenya 5
MY - Malesia 5
TW - Taiwan 5
CR - Costa Rica 4
EU - Europa 4
LT - Lituania 4
NG - Nigeria 4
NI - Nicaragua 4
OM - Oman 4
RO - Romania 4
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
GE - Georgia 3
GT - Guatemala 3
IL - Israele 3
KZ - Kazakistan 3
NP - Nepal 3
UY - Uruguay 3
AU - Australia 2
BG - Bulgaria 2
BH - Bahrain 2
CW - ???statistics.table.value.countryCode.CW??? 2
GR - Grecia 2
IR - Iran 2
IS - Islanda 2
JM - Giamaica 2
KH - Cambogia 2
KW - Kuwait 2
LB - Libano 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BW - Botswana 1
CH - Svizzera 1
CM - Camerun 1
DO - Repubblica Dominicana 1
GA - Gabon 1
HR - Croazia 1
Totale 11.288
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Città #
Ashburn 833
Singapore 494
Dallas 407
Jacksonville 277
Chandler 264
Fairfield 258
Council Bluffs 242
New York 227
San Jose 215
Ho Chi Minh City 207
Dublin 171
Marche 162
Hong Kong 159
Wilmington 156
Boardman 140
Beijing 133
Hanoi 133
Houston 119
Woodbridge 117
Seattle 101
Milan 100
Los Angeles 95
Ann Arbor 91
The Dalles 88
Ancona 87
Des Moines 86
Cambridge 81
Lauterbourg 64
Lawrence 60
Princeton 60
San Mateo 59
Centro 54
Moscow 48
Munich 44
Caracas 40
Hefei 39
Dakar 38
Abidjan 37
Da Nang 33
São Paulo 32
Brooklyn 31
Orem 30
San Francisco 27
San Diego 26
Baghdad 24
Haiphong 24
Denver 23
Helsinki 23
London 23
Phoenix 23
Santa Clara 23
Atlanta 22
Warsaw 22
Buffalo 21
Aversa 20
Chicago 19
Guangzhou 19
Rio de Janeiro 19
Carpentras 18
Rome 16
Shanghai 15
Tokyo 15
Boston 14
Nuremberg 14
Tashkent 14
Vienna 14
Washington 14
Porto Alegre 13
Scarlino 13
Brussels 12
Johannesburg 12
Ponte A Égola 12
Turin 12
Turku 12
Dong Ket 11
Ogden 11
Can Tho 10
Hải Dương 10
Kazan' 10
León 10
Montreal 10
Poplar 10
Amsterdam 9
Belo Horizonte 9
Civitanova Marche 9
Columbus 9
Paris 9
Quito 9
Lahore 8
Naples 8
Pune 8
Secaucus 8
Ascoli Piceno 7
Dhaka 7
Frankfurt am Main 7
Medellín 7
Mexico City 7
Ninh Bình 7
Nonantola 7
Salvador 7
Totale 6.914
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Nome #
Eubacterial pyridine nucleotide cycle: identification and characterization of the 'orphan enzyme' nmn deamidase 562
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival 448
THE DIFFERENTIAL BIOCHEMICAL PROPERTIES OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ISOZYMES ENABLE TO DETERMINE THEIR RELATIVE EXPRESSION LEVELS 323
Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases 246
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi 234
Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4 209
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC 199
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism 197
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues 197
Biological Activities of the Essential Oil from Erigeron floribundus 193
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 192
A circulating NAD biosynthetic enzyme is a novel modulator of inflammation 188
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD) 187
A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase 177
Genomics-driven reconstruction of Acinetobacter NAD metabolism: insights for antibacterial target selection 175
Enzymology of extracellular NAD metabolism 170
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement 169
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells 167
Novel assay identifies Nicotinamide riboside, the form of vitamin B3 that boosts metabolism, as a constituent of milk at levels comparable to Niacin 165
Synthesis and degradation of adenosine 5’-tetraphosphate by Nicotinamide and Nicotinate phosphoribosyltransferases 165
Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases. 164
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY 163
Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators 161
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. 161
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis 159
Identification of a novel human nicotinamide mononucleotide adenylyltransferase 158
Quinolinate salvage and insights for targeting NAD biosynthesis in group A Streptococci. 156
Bioinformatics and comparative genomics unveil an evolutionary conserved phage NAD metabolism 156
Exosome and microvesicle miRNAs belong to the pro-inflammatory secretome of senescent endothelial cells 155
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design 154
Human extracellular NAMPT and NAPRT mediate the inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction 154
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis. 147
Genomics and Enzymology of NAD Biosynthesis 146
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. 146
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation 144
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. 143
Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation 142
Glutamine versus Ammonia Utilization in the NAD Synthetase Family. 142
Biosintesi del NAD in Mycobacterium tubercolosis: clonaggio ed espressione dei geni nadD e nadR. 141
Characterization of the NAD biosynthesis in Francisella tularensis 140
Nicotinate phosphoribosyltransferase: a novel antiinfective target? 140
Characterization of the cytokine-like properties of extracellular nicotinamide phosphoribosyltransferase 139
Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria 139
Evolutionary and Comparative Genome Analysis of Phage NAD Metabolic Genes 135
Identification of Nicotinamide Mononucleotide Deamidase of the Bacterial Pyridine Nucleotide Cycle Reveals a Novel Broadly Conserved Amidohydrolase Family 135
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD 132
Structural requirements for the interaction of the enzyme nicotinamide phosphoribosyltransferase with Toll-like receptor 4 129
NAD biosynthesis enzymes from the bacterial world as valuable tools for vitamin B3 mononucleotides quantitation in mammals 129
Clonaggio ed espressione di geni da Mycobacterium tuberculosis coinvolti nella sintesi del NAD. 128
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon 127
Ammonia is the Physiological Substrate of ‘GAT-less’ Prokaryotic NAD Synthetase 126
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors 126
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns 122
Regulation of host immune responses to Schistosoma mansoni by the inhibition of the parasitic NAD salvage pathway 122
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. 119
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase 119
Targeting NAD biosynthesis in bacterial pathogens. Structure-Based development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD 118
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. 118
NAD homeostasis in the bacterial response to DNA/RNA damage. 115
The interaction between human NAMPT and NAPRT with TLR4: a focus on the molecular determinants 114
A novel route of NAD synthesis is uncovered in Francisella tularensis 113
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis 109
NAD biosynthesis under attack 109
Functions of the shared N-terminus of slow wallerian degeneration (WldS) and Ube4b proteins: a sequence required for axon protection and ubiquitination 108
Cloning and characterization of a new human NMN adenylyltransferase. 107
Una nuova NMN adeniltrasferasi umana: clonaggio, espressione eterologa e caratterizzazione della proteina KIAA0479. 104
S. pyogenes is reliant on salvage of host pyridine precursors for NAD synthesis: implications for pathogenesis and antibacterial intervention 104
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer 103
Mycobacterium tuberculosis NAD (P) BIOSYNTHETIC ENZYMES AS NOVEL ANTIMICROBIAL DRUG TARGETS 97
Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes 90
Structural biology of NAD metabolism in bacteria 90
The enzyme NMN deamidase of the bacterial pyridine nucleotide cycle is a novel, broadly conserved amidohydrolase 84
Mycobacterial tuberculosis NadD, a promise for targeting latent and drug-resistant tuberculosis 78
NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment 42
Arabidopsis thaliana nicotinate mononucleotide adenylyltransferase: unveiling the molecular determinants and evolutionary origin of nicotinic acid mononucleotide recognition 41
NAMPT AND NNMT ARE OVEREXPRESSED IN BRAF INHIBITORRESISTANT MELANOMA CELLS AS SOLUBLE FACTOR AND INTRACELLULAR ENZYME WITH PRELIMINARY EVIDENCE OF THEIR NUCLEAR LOCALIZATION 13
Totale 11.519
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Categoria #
all - tutte 49.023
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.023
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022447 0 128 6 11 14 19 24 18 35 45 58 89
2022/20231.005 77 91 64 81 67 150 2 70 239 12 110 42
2023/2024716 105 14 64 74 83 196 15 16 13 26 3 107
2024/20251.502 102 95 78 245 35 41 106 95 267 78 138 222
2025/20265.163 345 286 418 445 507 278 701 603 399 451 583 147
2026/2027381 199 182 0 0 0 0 0 0 0 0 0 0
Totale 11.519