IRIS
SORCI, Leonardo
 Distribuzione geografica
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Continente #
NA - Nord America 3.651
EU - Europa 2.203
AS - Asia 1.578
SA - Sud America 429
AF - Africa 76
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 7.945
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Nazione #
US - Stati Uniti d'America 3.603
SG - Singapore 652
IT - Italia 645
CN - Cina 386
DE - Germania 385
BR - Brasile 360
UA - Ucraina 263
RU - Federazione Russa 201
IE - Irlanda 173
VN - Vietnam 149
SE - Svezia 142
HK - Hong Kong 130
DK - Danimarca 93
TR - Turchia 86
GB - Regno Unito 74
FI - Finlandia 66
FR - Francia 59
KR - Corea 53
CI - Costa d'Avorio 36
AR - Argentina 30
PL - Polonia 23
AT - Austria 22
IN - India 22
BD - Bangladesh 21
CA - Canada 21
MX - Messico 20
NL - Olanda 20
BE - Belgio 13
JP - Giappone 13
ZA - Sudafrica 13
EC - Ecuador 12
ID - Indonesia 12
IQ - Iraq 10
PK - Pakistan 10
PH - Filippine 8
MA - Marocco 7
UZ - Uzbekistan 7
VE - Venezuela 7
CO - Colombia 6
EG - Egitto 6
ES - Italia 6
CL - Cile 4
EU - Europa 4
PT - Portogallo 4
PY - Paraguay 4
RO - Romania 4
AE - Emirati Arabi Uniti 3
KE - Kenya 3
LT - Lituania 3
PE - Perù 3
SN - Senegal 3
TN - Tunisia 3
AU - Australia 2
BO - Bolivia 2
BY - Bielorussia 2
ET - Etiopia 2
IR - Iran 2
IS - Islanda 2
NI - Nicaragua 2
NP - Nepal 2
SA - Arabia Saudita 2
SV - El Salvador 2
AL - Albania 1
AZ - Azerbaigian 1
BG - Bulgaria 1
BH - Bahrain 1
BW - Botswana 1
DZ - Algeria 1
GE - Georgia 1
GR - Grecia 1
GT - Guatemala 1
HN - Honduras 1
IL - Israele 1
JO - Giordania 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LB - Libano 1
LK - Sri Lanka 1
MY - Malesia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PA - Panama 1
UY - Uruguay 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 7.945
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Città #
Singapore 432
Ashburn 398
Dallas 327
Jacksonville 277
Chandler 264
Fairfield 258
New York 182
Dublin 170
Marche 162
Wilmington 156
Boardman 139
Hong Kong 130
Woodbridge 117
Beijing 111
Houston 105
Seattle 97
Ann Arbor 91
Des Moines 86
Milan 85
Ancona 83
Cambridge 80
Lawrence 60
Princeton 60
The Dalles 60
San Mateo 59
Ho Chi Minh City 55
Centro 54
Los Angeles 50
Munich 44
Hefei 39
Abidjan 36
Moscow 30
San Diego 26
Hanoi 25
São Paulo 23
Warsaw 22
Aversa 20
Guangzhou 19
Buffalo 17
Brooklyn 16
Rio de Janeiro 16
Chicago 15
London 15
Nuremberg 14
Vienna 14
Scarlino 13
Shanghai 13
Atlanta 12
Brussels 12
Ponte A Égola 12
Tokyo 12
Turku 12
Washington 12
Boston 11
Dong Ket 11
Porto Alegre 11
Kazan' 10
Poplar 10
Civitanova Marche 9
Turin 9
Council Bluffs 8
Johannesburg 8
Orem 8
Rome 8
Secaucus 8
Ascoli Piceno 7
Columbus 7
Haiphong 7
Wuhan 7
Amsterdam 6
Camerino 6
Da Nang 6
Denver 6
Liberty 6
Mexico City 6
Montreal 6
Paris 6
Perugia 6
Phoenix 6
Tashkent 6
Acquasanta Terme 5
Cairo 5
Campinas 5
Goiânia 5
Guarulhos 5
Helsinki 5
Manchester 5
Multan 5
Norwalk 5
Pune 5
Querétaro 5
Redmond 5
Salt Lake City 5
San Francisco 5
Santa Clara 5
Seoul 5
Stockholm 5
Tolentino 5
Aprilia 4
Baghdad 4
Totale 4.940
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Nome #
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival 384
THE DIFFERENTIAL BIOCHEMICAL PROPERTIES OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ISOZYMES ENABLE TO DETERMINE THEIR RELATIVE EXPRESSION LEVELS 290
Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases 196
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi 159
Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4 158
Biological Activities of the Essential Oil from Erigeron floribundus 150
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD) 142
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 140
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC 137
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues 136
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism 135
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement 135
A circulating NAD biosynthetic enzyme is a novel modulator of inflammation 133
Genomics-driven reconstruction of Acinetobacter NAD metabolism: insights for antibacterial target selection 130
Identification of a novel human nicotinamide mononucleotide adenylyltransferase 128
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. 128
Synthesis and degradation of adenosine 5’-tetraphosphate by Nicotinamide and Nicotinate phosphoribosyltransferases 127
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells 127
Human extracellular NAMPT and NAPRT mediate the inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction 127
Novel assay identifies Nicotinamide riboside, the form of vitamin B3 that boosts metabolism, as a constituent of milk at levels comparable to Niacin 126
Exosome and microvesicle miRNAs belong to the pro-inflammatory secretome of senescent endothelial cells 123
Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases. 120
Enzymology of extracellular NAD metabolism 120
Bioinformatics and comparative genomics unveil an evolutionary conserved phage NAD metabolism 117
Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators 116
Characterization of the NAD biosynthesis in Francisella tularensis 114
Nicotinate phosphoribosyltransferase: a novel antiinfective target? 112
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation 112
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. 110
Evolutionary and Comparative Genome Analysis of Phage NAD Metabolic Genes 109
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis. 109
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. 109
Identification of Nicotinamide Mononucleotide Deamidase of the Bacterial Pyridine Nucleotide Cycle Reveals a Novel Broadly Conserved Amidohydrolase Family 109
A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase 106
Quinolinate salvage and insights for targeting NAD biosynthesis in group A Streptococci. 106
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD 105
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY 105
Biosintesi del NAD in Mycobacterium tubercolosis: clonaggio ed espressione dei geni nadD e nadR. 104
Glutamine versus Ammonia Utilization in the NAD Synthetase Family. 103
Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria 102
Genomics and Enzymology of NAD Biosynthesis 101
Clonaggio ed espressione di geni da Mycobacterium tuberculosis coinvolti nella sintesi del NAD. 100
Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation 99
NAD biosynthesis enzymes from the bacterial world as valuable tools for vitamin B3 mononucleotides quantitation in mammals 98
Structural requirements for the interaction of the enzyme nicotinamide phosphoribosyltransferase with Toll-like receptor 4 96
Ammonia is the Physiological Substrate of ‘GAT-less’ Prokaryotic NAD Synthetase 96
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns 95
Characterization of the cytokine-like properties of extracellular nicotinamide phosphoribosyltransferase 95
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon 95
Eubacterial pyridine nucleotide cycle: identification and characterization of the 'orphan enzyme' nmn deamidase 93
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. 92
NAD homeostasis in the bacterial response to DNA/RNA damage. 92
Targeting NAD biosynthesis in bacterial pathogens. Structure-Based development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD 91
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase 90
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis 89
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. 88
A novel route of NAD synthesis is uncovered in Francisella tularensis 87
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors 87
Functions of the shared N-terminus of slow wallerian degeneration (WldS) and Ube4b proteins: a sequence required for axon protection and ubiquitination 86
Regulation of host immune responses to Schistosoma mansoni by the inhibition of the parasitic NAD salvage pathway 85
Cloning and characterization of a new human NMN adenylyltransferase. 80
S. pyogenes is reliant on salvage of host pyridine precursors for NAD synthesis: implications for pathogenesis and antibacterial intervention 79
NAD biosynthesis under attack 78
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer 76
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis 74
Una nuova NMN adeniltrasferasi umana: clonaggio, espressione eterologa e caratterizzazione della proteina KIAA0479. 74
The interaction between human NAMPT and NAPRT with TLR4: a focus on the molecular determinants 72
Mycobacterium tuberculosis NAD (P) BIOSYNTHETIC ENZYMES AS NOVEL ANTIMICROBIAL DRUG TARGETS 70
Structural biology of NAD metabolism in bacteria 69
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design 60
The enzyme NMN deamidase of the bacterial pyridine nucleotide cycle is a novel, broadly conserved amidohydrolase 57
Mycobacterial tuberculosis NadD, a promise for targeting latent and drug-resistant tuberculosis 54
Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes 53
Arabidopsis thaliana nicotinate mononucleotide adenylyltransferase: unveiling the molecular determinants and evolutionary origin of nicotinic acid mononucleotide recognition 6
NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment 3
Totale 8.159
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Categoria #
all - tutte 41.243
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.243
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021492 0 0 0 0 0 62 77 55 94 65 93 46
2021/2022470 23 128 6 11 14 19 24 18 35 45 58 89
2022/20231.005 77 91 64 81 67 150 2 70 239 12 110 42
2023/2024716 105 14 64 74 83 196 15 16 13 26 3 107
2024/20251.502 102 95 78 245 35 41 106 95 267 78 138 222
2025/20262.184 345 286 418 445 507 183 0 0 0 0 0 0
Totale 8.159