IRIS
SORCI, Leonardo
 Distribuzione geografica
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Continente #
NA - Nord America 5.751
AS - Asia 2.698
EU - Europa 2.659
SA - Sud America 632
Continente sconosciuto - Info sul continente non disponibili 227
AF - Africa 161
OC - Oceania 3
Totale 12.131
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Nazione #
US - Stati Uniti d'America 5.601
SG - Singapore 805
IT - Italia 763
VN - Vietnam 637
CN - Cina 581
BR - Brasile 460
DE - Germania 391
RU - Federazione Russa 350
UA - Ucraina 269
IE - Irlanda 174
FR - Francia 163
HK - Hong Kong 162
SE - Svezia 146
DK - Danimarca 95
GB - Regno Unito 94
BD - Bangladesh 93
TR - Turchia 93
FI - Finlandia 84
KR - Corea 63
CA - Canada 56
VE - Venezuela 56
IQ - Iraq 47
MX - Messico 44
AR - Argentina 41
IN - India 41
SN - Senegal 38
CI - Costa d'Avorio 37
NL - Olanda 27
ZA - Sudafrica 27
EC - Ecuador 25
PK - Pakistan 24
PL - Polonia 24
AT - Austria 23
CO - Colombia 20
ID - Indonesia 19
JP - Giappone 19
PH - Filippine 18
UZ - Uzbekistan 16
BE - Belgio 13
DZ - Algeria 13
MA - Marocco 13
AE - Emirati Arabi Uniti 10
CR - Costa Rica 10
ES - Italia 10
SV - El Salvador 10
PY - Paraguay 9
EG - Egitto 8
PE - Perù 8
TH - Thailandia 8
CL - Cile 7
JO - Giordania 7
NI - Nicaragua 7
SA - Arabia Saudita 7
HN - Honduras 6
PT - Portogallo 6
TN - Tunisia 6
AZ - Azerbaigian 5
GT - Guatemala 5
KE - Kenya 5
MY - Malesia 5
TW - Taiwan 5
EU - Europa 4
JM - Giamaica 4
LT - Lituania 4
NG - Nigeria 4
OM - Oman 4
RO - Romania 4
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
CW - ???statistics.table.value.countryCode.CW??? 3
ET - Etiopia 3
GE - Georgia 3
IL - Israele 3
KZ - Kazakistan 3
NP - Nepal 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AU - Australia 2
BG - Bulgaria 2
BH - Bahrain 2
GR - Grecia 2
IR - Iran 2
IS - Islanda 2
KH - Cambogia 2
KW - Kuwait 2
LB - Libano 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BW - Botswana 1
CH - Svizzera 1
CM - Camerun 1
DO - Repubblica Dominicana 1
GA - Gabon 1
HR - Croazia 1
Totale 11.900
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Città #
Ashburn 944
Singapore 494
Dallas 409
San Jose 316
Council Bluffs 293
Jacksonville 277
Chandler 264
Fairfield 258
New York 232
Ho Chi Minh City 207
Dublin 172
Marche 162
Hong Kong 159
Wilmington 158
Boardman 140
Beijing 133
Hanoi 133
Houston 119
Woodbridge 117
Milan 105
Seattle 101
Los Angeles 100
Ann Arbor 91
The Dalles 88
Ancona 87
Des Moines 86
Cambridge 81
Lauterbourg 64
Princeton 63
Lawrence 60
San Mateo 59
Centro 54
Moscow 48
Munich 44
Caracas 40
Hefei 39
Dakar 38
Abidjan 37
Phoenix 37
Brooklyn 34
Da Nang 33
São Paulo 33
Santa Clara 31
Orem 30
San Francisco 29
Atlanta 27
Chicago 27
San Diego 26
Baghdad 24
Buffalo 24
Denver 24
Haiphong 24
Helsinki 23
London 23
Warsaw 22
Aversa 20
Rome 20
Guangzhou 19
Rio de Janeiro 19
Carpentras 18
Tokyo 17
Shanghai 15
Turin 15
Boston 14
Nuremberg 14
Tashkent 14
Vienna 14
Washington 14
Naples 13
Porto Alegre 13
Scarlino 13
Brussels 12
Johannesburg 12
Montreal 12
Ponte A Égola 12
Turku 12
Columbus 11
Dong Ket 11
Ogden 11
Toronto 11
Can Tho 10
Hải Dương 10
Kazan' 10
León 10
Poplar 10
Amsterdam 9
Belo Horizonte 9
Civitanova Marche 9
Paris 9
Quito 9
San José 9
Lahore 8
Pune 8
San Salvador 8
Secaucus 8
Ascoli Piceno 7
Dhaka 7
Frankfurt am Main 7
Managua 7
Medellín 7
Totale 7.270
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Nome #
Eubacterial pyridine nucleotide cycle: identification and characterization of the 'orphan enzyme' nmn deamidase 569
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival 454
THE DIFFERENTIAL BIOCHEMICAL PROPERTIES OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ISOZYMES ENABLE TO DETERMINE THEIR RELATIVE EXPRESSION LEVELS 328
Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases 250
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi 241
Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4 222
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC 215
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism 203
A circulating NAD biosynthetic enzyme is a novel modulator of inflammation 202
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues 201
Biological Activities of the Essential Oil from Erigeron floribundus 199
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 198
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD) 192
A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase 185
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design 183
Genomics-driven reconstruction of Acinetobacter NAD metabolism: insights for antibacterial target selection 182
Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases. 181
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells 176
Enzymology of extracellular NAD metabolism 176
Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators 175
Novel assay identifies Nicotinamide riboside, the form of vitamin B3 that boosts metabolism, as a constituent of milk at levels comparable to Niacin 175
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement 175
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY 170
Human extracellular NAMPT and NAPRT mediate the inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction 170
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. 169
Synthesis and degradation of adenosine 5’-tetraphosphate by Nicotinamide and Nicotinate phosphoribosyltransferases 169
Identification of a novel human nicotinamide mononucleotide adenylyltransferase 168
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis 168
Quinolinate salvage and insights for targeting NAD biosynthesis in group A Streptococci. 163
Exosome and microvesicle miRNAs belong to the pro-inflammatory secretome of senescent endothelial cells 163
Nicotinate phosphoribosyltransferase: a novel antiinfective target? 160
Bioinformatics and comparative genomics unveil an evolutionary conserved phage NAD metabolism 159
Evolutionary and Comparative Genome Analysis of Phage NAD Metabolic Genes 156
Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation 155
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis. 154
Genomics and Enzymology of NAD Biosynthesis 151
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. 151
Characterization of the cytokine-like properties of extracellular nicotinamide phosphoribosyltransferase 150
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation 150
Biosintesi del NAD in Mycobacterium tubercolosis: clonaggio ed espressione dei geni nadD e nadR. 149
Glutamine versus Ammonia Utilization in the NAD Synthetase Family. 149
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. 148
Characterization of the NAD biosynthesis in Francisella tularensis 147
NAD biosynthesis enzymes from the bacterial world as valuable tools for vitamin B3 mononucleotides quantitation in mammals 144
Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria 142
Identification of Nicotinamide Mononucleotide Deamidase of the Bacterial Pyridine Nucleotide Cycle Reveals a Novel Broadly Conserved Amidohydrolase Family 140
Structural requirements for the interaction of the enzyme nicotinamide phosphoribosyltransferase with Toll-like receptor 4 138
Clonaggio ed espressione di geni da Mycobacterium tuberculosis coinvolti nella sintesi del NAD. 138
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD 137
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns 131
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon 131
Ammonia is the Physiological Substrate of ‘GAT-less’ Prokaryotic NAD Synthetase 131
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors 130
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. 127
Regulation of host immune responses to Schistosoma mansoni by the inhibition of the parasitic NAD salvage pathway 127
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase 124
The interaction between human NAMPT and NAPRT with TLR4: a focus on the molecular determinants 123
Targeting NAD biosynthesis in bacterial pathogens. Structure-Based development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD 122
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. 122
NAD homeostasis in the bacterial response to DNA/RNA damage. 120
A novel route of NAD synthesis is uncovered in Francisella tularensis 118
Cloning and characterization of a new human NMN adenylyltransferase. 116
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis 115
NAD biosynthesis under attack 114
Functions of the shared N-terminus of slow wallerian degeneration (WldS) and Ube4b proteins: a sequence required for axon protection and ubiquitination 113
Una nuova NMN adeniltrasferasi umana: clonaggio, espressione eterologa e caratterizzazione della proteina KIAA0479. 111
Mycobacterium tuberculosis NAD (P) BIOSYNTHETIC ENZYMES AS NOVEL ANTIMICROBIAL DRUG TARGETS 111
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer 109
S. pyogenes is reliant on salvage of host pyridine precursors for NAD synthesis: implications for pathogenesis and antibacterial intervention 107
Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes 96
Structural biology of NAD metabolism in bacteria 94
The enzyme NMN deamidase of the bacterial pyridine nucleotide cycle is a novel, broadly conserved amidohydrolase 89
Mycobacterial tuberculosis NadD, a promise for targeting latent and drug-resistant tuberculosis 84
NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment 51
Arabidopsis thaliana nicotinate mononucleotide adenylyltransferase: unveiling the molecular determinants and evolutionary origin of nicotinic acid mononucleotide recognition 48
NAMPT AND NNMT ARE OVEREXPRESSED IN BRAF INHIBITORRESISTANT MELANOMA CELLS AS SOLUBLE FACTOR AND INTRACELLULAR ENZYME WITH PRELIMINARY EVIDENCE OF THEIR NUCLEAR LOCALIZATION 27
Totale 12.131
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Categoria #
all - tutte 51.585
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.585
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022313 0 0 0 11 14 19 24 18 35 45 58 89
2022/20231.005 77 91 64 81 67 150 2 70 239 12 110 42
2023/2024716 105 14 64 74 83 196 15 16 13 26 3 107
2024/20251.502 102 95 78 245 35 41 106 95 267 78 138 222
2025/20265.163 345 286 418 445 507 278 701 603 399 451 583 147
2026/2027993 199 229 276 289 0 0 0 0 0 0 0 0
Totale 12.131