IRIS
SORCI, Leonardo
 Distribuzione geografica
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Continente #
NA - Nord America 4.224
AS - Asia 2.581
EU - Europa 2.555
SA - Sud America 620
AF - Africa 161
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 10.149
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Nazione #
US - Stati Uniti d'America 4.143
SG - Singapore 757
IT - Italia 681
VN - Vietnam 637
CN - Cina 552
BR - Brasile 452
DE - Germania 391
RU - Federazione Russa 350
UA - Ucraina 269
IE - Irlanda 173
FR - Francia 162
HK - Hong Kong 158
SE - Svezia 143
DK - Danimarca 94
TR - Turchia 93
FI - Finlandia 84
GB - Regno Unito 82
BD - Bangladesh 69
KR - Corea 61
VE - Venezuela 55
IQ - Iraq 46
MX - Messico 43
AR - Argentina 41
IN - India 40
SN - Senegal 38
CI - Costa d'Avorio 37
ZA - Sudafrica 27
EC - Ecuador 24
NL - Olanda 24
PK - Pakistan 24
PL - Polonia 24
AT - Austria 23
CA - Canada 21
CO - Colombia 19
ID - Indonesia 18
PH - Filippine 17
JP - Giappone 16
UZ - Uzbekistan 16
BE - Belgio 13
DZ - Algeria 13
MA - Marocco 13
ES - Italia 10
AE - Emirati Arabi Uniti 9
EG - Egitto 8
PE - Perù 8
PY - Paraguay 8
TH - Thailandia 8
CL - Cile 7
JO - Giordania 7
SA - Arabia Saudita 7
TN - Tunisia 6
AZ - Azerbaigian 5
KE - Kenya 5
PT - Portogallo 5
TW - Taiwan 5
EU - Europa 4
LT - Lituania 4
MY - Malesia 4
NG - Nigeria 4
OM - Oman 4
RO - Romania 4
SV - El Salvador 4
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
GE - Georgia 3
IL - Israele 3
KZ - Kazakistan 3
NI - Nicaragua 3
NP - Nepal 3
UY - Uruguay 3
AU - Australia 2
BG - Bulgaria 2
BH - Bahrain 2
GR - Grecia 2
GT - Guatemala 2
HN - Honduras 2
IR - Iran 2
IS - Islanda 2
KH - Cambogia 2
LB - Libano 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BW - Botswana 1
CH - Svizzera 1
CM - Camerun 1
DO - Repubblica Dominicana 1
GA - Gabon 1
HR - Croazia 1
IM - Isola di Man 1
JM - Giamaica 1
KG - Kirghizistan 1
KW - Kuwait 1
LK - Sri Lanka 1
MD - Moldavia 1
Totale 10.140
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Città #
Ashburn 666
Singapore 487
Dallas 328
Jacksonville 277
Chandler 264
Fairfield 258
Ho Chi Minh City 207
New York 184
Dublin 170
San Jose 165
Marche 162
Wilmington 156
Hong Kong 155
Boardman 140
Hanoi 133
Beijing 126
Woodbridge 117
Houston 105
Seattle 97
Ann Arbor 91
The Dalles 88
Ancona 87
Milan 87
Des Moines 86
Cambridge 80
Lauterbourg 64
Lawrence 60
Princeton 60
San Mateo 59
Centro 54
Los Angeles 53
Moscow 48
Munich 44
Caracas 40
Hefei 39
Dakar 38
Abidjan 37
Da Nang 33
São Paulo 32
Council Bluffs 26
San Diego 26
Haiphong 24
Baghdad 23
Helsinki 23
Warsaw 22
Aversa 20
Guangzhou 19
Orem 19
Rio de Janeiro 19
Buffalo 18
Carpentras 18
London 18
Brooklyn 17
Chicago 15
Tokyo 15
Nuremberg 14
Shanghai 14
Tashkent 14
Vienna 14
Scarlino 13
Atlanta 12
Brussels 12
Johannesburg 12
Ponte A Égola 12
Porto Alegre 12
Turku 12
Washington 12
Boston 11
Dong Ket 11
Ogden 11
Can Tho 10
Hải Dương 10
Kazan' 10
León 10
Poplar 10
Rome 10
Santa Clara 10
Belo Horizonte 9
Civitanova Marche 9
Paris 9
Quito 9
Turin 9
Amsterdam 8
Lahore 8
Pune 8
Secaucus 8
Ascoli Piceno 7
Columbus 7
Frankfurt am Main 7
Medellín 7
Mexico City 7
Naples 7
Ninh Bình 7
Nonantola 7
Salvador 7
Wuhan 7
Cairo 6
Camerino 6
Chennai 6
Denver 6
Totale 6.126
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Nome #
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival 418
THE DIFFERENTIAL BIOCHEMICAL PROPERTIES OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ISOZYMES ENABLE TO DETERMINE THEIR RELATIVE EXPRESSION LEVELS 317
Genomics-Guided Analysis of NAD Recycling Yields Functional Elucidation of COG1058 as a New Family of Pyrophosphatases 224
Diverse biological effects of the essential oil from Iranian Trachyspermum ammi 203
Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4 199
Biological Activities of the Essential Oil from Erigeron floribundus 188
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism 183
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues 183
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC 181
A circulating NAD biosynthetic enzyme is a novel modulator of inflammation 179
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD) 175
Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family 175
Genomics-driven reconstruction of Acinetobacter NAD metabolism: insights for antibacterial target selection 169
Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells 163
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement 161
Enzymology of extracellular NAD metabolism 159
Synthesis and degradation of adenosine 5’-tetraphosphate by Nicotinamide and Nicotinate phosphoribosyltransferases 157
Novel assay identifies Nicotinamide riboside, the form of vitamin B3 that boosts metabolism, as a constituent of milk at levels comparable to Niacin 156
Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators 155
A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase 154
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism. 154
Characterization of bacterial NMN deamidase as a Ser/Lys hydrolase expands diversity of serine amidohydrolases. 154
Human extracellular NAMPT and NAPRT mediate the inflammatory response through TLR4-binding: molecular insights into the mechanism of interaction 152
Exosome and microvesicle miRNAs belong to the pro-inflammatory secretome of senescent endothelial cells 151
Identification of a novel human nicotinamide mononucleotide adenylyltransferase 149
Bioinformatics and comparative genomics unveil an evolutionary conserved phage NAD metabolism 145
Quinolinate salvage and insights for targeting NAD biosynthesis in group A Streptococci. 144
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis. 143
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation 139
Biosintesi del NAD in Mycobacterium tubercolosis: clonaggio ed espressione dei geni nadD e nadR. 138
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. 138
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design 137
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. 137
Glutamine versus Ammonia Utilization in the NAD Synthetase Family. 137
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY 135
Genomics and Enzymology of NAD Biosynthesis 135
Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation 134
Characterization of the NAD biosynthesis in Francisella tularensis 134
Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis 131
Nicotinate phosphoribosyltransferase: a novel antiinfective target? 130
Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria 128
Identification of Nicotinamide Mononucleotide Deamidase of the Bacterial Pyridine Nucleotide Cycle Reveals a Novel Broadly Conserved Amidohydrolase Family 128
Evolutionary and Comparative Genome Analysis of Phage NAD Metabolic Genes 126
Structural requirements for the interaction of the enzyme nicotinamide phosphoribosyltransferase with Toll-like receptor 4 125
Characterization of the cytokine-like properties of extracellular nicotinamide phosphoribosyltransferase 123
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD 122
Clonaggio ed espressione di geni da Mycobacterium tuberculosis coinvolti nella sintesi del NAD. 122
NAD biosynthesis enzymes from the bacterial world as valuable tools for vitamin B3 mononucleotides quantitation in mammals 122
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon 119
Eubacterial pyridine nucleotide cycle: identification and characterization of the 'orphan enzyme' nmn deamidase 119
Ammonia is the Physiological Substrate of ‘GAT-less’ Prokaryotic NAD Synthetase 118
The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors 116
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns 115
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. 115
Targeting NAD biosynthesis in bacterial pathogens. Structure-Based development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD 114
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase 114
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. 113
NAD homeostasis in the bacterial response to DNA/RNA damage. 109
The interaction between human NAMPT and NAPRT with TLR4: a focus on the molecular determinants 108
Regulation of host immune responses to Schistosoma mansoni by the inhibition of the parasitic NAD salvage pathway 108
A novel route of NAD synthesis is uncovered in Francisella tularensis 105
NAD biosynthesis under attack 105
Functions of the shared N-terminus of slow wallerian degeneration (WldS) and Ube4b proteins: a sequence required for axon protection and ubiquitination 104
Cloning and characterization of a new human NMN adenylyltransferase. 103
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis 101
Una nuova NMN adeniltrasferasi umana: clonaggio, espressione eterologa e caratterizzazione della proteina KIAA0479. 100
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer 98
S. pyogenes is reliant on salvage of host pyridine precursors for NAD synthesis: implications for pathogenesis and antibacterial intervention 94
Mycobacterium tuberculosis NAD (P) BIOSYNTHETIC ENZYMES AS NOVEL ANTIMICROBIAL DRUG TARGETS 92
Structural biology of NAD metabolism in bacteria 86
Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes 84
The enzyme NMN deamidase of the bacterial pyridine nucleotide cycle is a novel, broadly conserved amidohydrolase 76
Mycobacterial tuberculosis NadD, a promise for targeting latent and drug-resistant tuberculosis 75
Arabidopsis thaliana nicotinate mononucleotide adenylyltransferase: unveiling the molecular determinants and evolutionary origin of nicotinic acid mononucleotide recognition 33
NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment 31
Totale 10.367
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Categoria #
all - tutte 44.481
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.481
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021204 0 0 0 0 0 0 0 0 0 65 93 46
2021/2022470 23 128 6 11 14 19 24 18 35 45 58 89
2022/20231.005 77 91 64 81 67 150 2 70 239 12 110 42
2023/2024716 105 14 64 74 83 196 15 16 13 26 3 107
2024/20251.502 102 95 78 245 35 41 106 95 267 78 138 222
2025/20264.392 345 286 418 445 507 278 701 603 399 410 0 0
Totale 10.367