NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors.
SORCI, Leonardo;Mazzola F;RAFFAELLI, Nadia;MAGNI, GIULIO
2005-01-01
Abstract
NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzymeFile in questo prodotto:
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