NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors / Franchetti, P; Petrelli, R; Cappellacci, L; Pasqualini, M; Vita, P; Sorci, Leonardo; Mazzola, F; Raffaelli, Nadia; Magni, Giulio. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - 24:(2005), pp. 477-479. [10.1081/NCN-200060013]
Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors.
SORCI, Leonardo;Mazzola F;RAFFAELLI, Nadia;MAGNI, GIULIO
2005-01-01
Abstract
NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzymeFile in questo prodotto:
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