The role of insulin resistance in predicting virological response to therapy of chronic hepatitis C is debated. We assessed the association between basal (defined as homeostasis model assessment of insulin resistance (HOMA-IR)>2) and post-load insulin resistance (as oral glucose insulin sensitivity index<9.8 mg/kg/min) with the rapid and sustained virological responses in chronic hepatitis C.Observational prospective study of 124 treatment-naïve patients with chronic hepatitis C not fulfilling the metabolic syndrome criteria, adherent to a standard treatment with pegylated interferon alpha plus ribavirin.Insulin resistance was detected in 50\% (by HOMA-IR) and 29\% (by oral glucose insulin sensitivity index) of patients. Independent predictors of rapid virologic response were hepatitis C virus (HCV) genotype 2 (odds ratio 5.66; 95\% confidence interval 1.88-17.01), HCV genotype 3 (odds ratio 5.23; 95\% confidence interval 1.84-14.84) and lower basal ferritin levels (odds ratio 0.99; 95\% confidence interval 0.993-0.998). Independent predictors of sustained virologic response were HCV genotype 2 (odds ratio 19.54; 95\% confidence interval 2.29-166.41) and HCV genotype 3 (odds ratio 3.24; 95\% confidence interval 1.10-9.58). Rapid virologic response was by itself predictive of sustained virologic response (odds ratio 40.90; 95\% confidence interval 5.37-311.53).Insulin resistance, measured by both static and dynamic methods, does not predict rapid or sustained virologic response in chronic hepatitis C patients without the metabolic syndrome.
Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome / G., Fattovich; SVEGLIATI BARONI, Gianluca; M., Pasino; I., Pierantonelli; L., Covolo; D., Ieluzzi; N., Passigato; A., Tonon; M. G., Faraci; M., Guido; F., Negro. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 44:(2012), pp. 419-425. [10.1016/j.dld.2011.12.006]
Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome.
SVEGLIATI BARONI, Gianluca;
2012-01-01
Abstract
The role of insulin resistance in predicting virological response to therapy of chronic hepatitis C is debated. We assessed the association between basal (defined as homeostasis model assessment of insulin resistance (HOMA-IR)>2) and post-load insulin resistance (as oral glucose insulin sensitivity index<9.8 mg/kg/min) with the rapid and sustained virological responses in chronic hepatitis C.Observational prospective study of 124 treatment-naïve patients with chronic hepatitis C not fulfilling the metabolic syndrome criteria, adherent to a standard treatment with pegylated interferon alpha plus ribavirin.Insulin resistance was detected in 50\% (by HOMA-IR) and 29\% (by oral glucose insulin sensitivity index) of patients. Independent predictors of rapid virologic response were hepatitis C virus (HCV) genotype 2 (odds ratio 5.66; 95\% confidence interval 1.88-17.01), HCV genotype 3 (odds ratio 5.23; 95\% confidence interval 1.84-14.84) and lower basal ferritin levels (odds ratio 0.99; 95\% confidence interval 0.993-0.998). Independent predictors of sustained virologic response were HCV genotype 2 (odds ratio 19.54; 95\% confidence interval 2.29-166.41) and HCV genotype 3 (odds ratio 3.24; 95\% confidence interval 1.10-9.58). Rapid virologic response was by itself predictive of sustained virologic response (odds ratio 40.90; 95\% confidence interval 5.37-311.53).Insulin resistance, measured by both static and dynamic methods, does not predict rapid or sustained virologic response in chronic hepatitis C patients without the metabolic syndrome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
