The livers of rats given ethanol for 5 weeks showed marked structural alterations of hepatocytes of acinar zone 3 including mitochondrial pleomorphism, increased smooth endoplasmic reticulum and deposition of small (less than 0.5 micron) lipid droplets. In addition, apoptotic bodies involving altered parenchymal cells were frequently observed, together with prominent mononuclear infiltrates adjacent to the terminal hepatic veins. It is suggested that 'age' of liver cells may play a role in the preferential perivenular localization of early ethanol-induced liver damage.
Subcellular changes and apoptosis induced by ethanol in rat liver / Benedetti, Antonio; E., Brunelli; R., Risicato; T., Cilluffo; A. M., Jézéquel; Orlandi, Francesco. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 6:(1988), pp. 137-143.
Subcellular changes and apoptosis induced by ethanol in rat liver.
BENEDETTI, Antonio;ORLANDI, FRANCESCO
1988-01-01
Abstract
The livers of rats given ethanol for 5 weeks showed marked structural alterations of hepatocytes of acinar zone 3 including mitochondrial pleomorphism, increased smooth endoplasmic reticulum and deposition of small (less than 0.5 micron) lipid droplets. In addition, apoptotic bodies involving altered parenchymal cells were frequently observed, together with prominent mononuclear infiltrates adjacent to the terminal hepatic veins. It is suggested that 'age' of liver cells may play a role in the preferential perivenular localization of early ethanol-induced liver damage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
