Abstract The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.
Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides / Giacometti, Andrea; Cirioni, Oscar; Ghiselli, Roberto; Orlandoni, Francesco; D'Amato, G; Kamysz, W; Mocchegiani, Federico; Sisti, V; Silvestri, Carmela; Łukasiak, J; Rocchi, M; Saba, Vittorio; Scalise, Giorgio. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 48:8(2004), pp. 3162-3164. [10.1128/AAC.48.8.3162-3164.2004]
Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides.
GIACOMETTI, Andrea;CIRIONI, OSCAR;GHISELLI, ROBERTO;ORLANDONI, FRANCESCO;MOCCHEGIANI, FEDERICO;SILVESTRI, Carmela;SABA, Vittorio;SCALISE, Giorgio
2004-01-01
Abstract
Abstract The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
