Mediterranean diet health benefits have been partially attributed to the dietary consumption of extra virgin olive oil (VOO). VOO from Campania (Italy) was investigated for its phenolic profile, inhibitory activity against a-glucosidase and a -amilase, as well as ACE, which has been linked to hyperglycemia-associated hypertension. The HPLC analysis revealed the presence of 3,4-DHPEA and p-HPEA, 3,4-DHPEA-ADE and p-HPEA-EDA. Apigenin and luteolin were also identified.-glucosidase and a -amylase, respectively. Phenolic extract showed IC50 values of 184 and 258 ug/mL, against a-glucosidase and a-amilase, respectively. Interesting was also the ACE inhibitory activity (IC50 98.6 ug/mL). VOO extract hypoglycaemic and ACE inhibitory activities showed in the present work provide a strong biochemical rationale for further in vivo studies. Actually, daily consumption of VOO has not been shown to provide clinical benefits to people with diabetes and hypertension but a possible preventive effct cannot be relued out.
In vitro evaluation of phenolics from Italian Extra Virgin Olive Oil for Diabetes Type II, obesity and hypertension management / Loizzo, M. R.; DI LECCE, Giuseppe; Menichini, F.; Boselli, Emanuele; Menichini, F.; Frega, Natale Giuseppe. - In: ANNALS OF NUTRITION AND METABOLISM. - ISSN 0250-6807. - 55:(2009), pp. 595-595. [10.1159/000248545]