Abstract: Starting from chiral 3,4-trans-disubstituted pyrrolidin-2-ones 11a and 11b, obtained from a Baylis–Hillman adduct, conformationally restricted analogues of both (S)-β-homoserine, 17, and (S)-aspartic acid, 21, were synthesized, respectively, and these compounds are suitable either for introduction in peptidomimetics or for synthesis of novel β-foldamers. Keywords: Amino acids; Analogues; Baylis–Hillman; Peptidomimetics; Conformational constrictions
Conformationally Restricted Analogues of both (S)-beta-Homoserine and (S)-Aspartic Acid from Chiral 3-Acylamino Pyrrolidin-2-ones / Galeazzi, Roberta; Martelli, G.; Orena, Mario; Rinaldi, Samuele; Sabatino, P.. - In: TETRAHEDRON. - ISSN 0040-4020. - 61:(2005), pp. 5465-5473. [10.1016/j.tet.2005.03.129]
Conformationally Restricted Analogues of both (S)-beta-Homoserine and (S)-Aspartic Acid from Chiral 3-Acylamino Pyrrolidin-2-ones
GALEAZZI, ROBERTA;ORENA, MARIO;RINALDI, SAMUELE;
2005-01-01
Abstract
Abstract: Starting from chiral 3,4-trans-disubstituted pyrrolidin-2-ones 11a and 11b, obtained from a Baylis–Hillman adduct, conformationally restricted analogues of both (S)-β-homoserine, 17, and (S)-aspartic acid, 21, were synthesized, respectively, and these compounds are suitable either for introduction in peptidomimetics or for synthesis of novel β-foldamers. Keywords: Amino acids; Analogues; Baylis–Hillman; Peptidomimetics; Conformational constrictionsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
