Starting from (3S,4R,1′S)-3-amino-2-oxo-1-[1′-(4-methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a β-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations.
Synthesis and structural characterization as 12-helix of the hexamer of a β-amino acid tethered to a pyrrolidin-2-one ring / Menegazzo, I; Fries, A; Mammi, S; Galeazzi, Roberta; Martelli, G; Orena, Mario; Rinaldi, Samuele. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 47:(2006), pp. 4915-4917. [10.1039/b612071g]
Synthesis and structural characterization as 12-helix of the hexamer of a β-amino acid tethered to a pyrrolidin-2-one ring
GALEAZZI, ROBERTA;ORENA, MARIO;RINALDI, SAMUELE
2006-01-01
Abstract
Starting from (3S,4R,1′S)-3-amino-2-oxo-1-[1′-(4-methoxyphenylethyl)]pyrrolidine carboxylic acid (2), the first synthesis of a β-foldamer containing pyrrolidin-2-one rings is described, whose 12-helix conformation is assigned by NMR analysis and confirmed by molecular dynamics (MD) simulations.File in questo prodotto:
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