Abstract The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.
Treatment of Staphylococcus aureus Biofilm infection by the quorum sensing inhibitor RIP / Balaban, N; Cirioni, O; Giacometti, Andrea; Ghiselli, Roberto; Braunstein, Jb; Silvestri, C; Mocchegiani, Federico; Saba, Vittorio; Scalise, Giorgio. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 51:6(2007), pp. 2226-2229. [10.1128/AAC.01097-06]
Treatment of Staphylococcus aureus Biofilm infection by the quorum sensing inhibitor RIP
Cirioni O;GIACOMETTI, Andrea;GHISELLI, ROBERTO;MOCCHEGIANI, FEDERICO;SABA, Vittorio;SCALISE, Giorgio
2007-01-01
Abstract
Abstract The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
