Summary: The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.
SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans / Piva, Francesco; Giulietti, M; Nocchi, L; Principato, Giovanni. - In: BIOINFORMATICS. - ISSN 1367-4803. - STAMPA. - 25:(2009), pp. 1211-1213. [10.1093/bioinformatics/btp124]
SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans
PIVA, Francesco
;GIULIETTI M;PRINCIPATO, GIOVANNI
2009-01-01
Abstract
Summary: The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
