In bladder cancer (BC), the evaluation of lymph node (LN) involvement at preoperative imaging lacks specificity. Since neoangiogenesis is paired with lymphatic involvement, this study aims to evaluate the presence of perivesical venous ectasia as an indirect sign of LN involvement, together with other conventional CT findings. All the patients who underwent radical cystectomy (RC) for BC between January 2017 and December 2019 with available preoperative contrast-enhanced CT (CECT) within 1 month before surgery were included. Patients without available pathological reports (and pTNM stage) or who underwent neoadjuvant treatments and palliative RC were excluded. Two readers in blind assessed the nodal shape and hilum, the short axis, and the contrast enhancement of suspicious pelvic LNs, the Largest Venous Diameter (LVD) efferent to the lesion, and the extravesical tumor invasion. In total, 38 patients (33 males) were included: 17 pT2, 17 pT3, 4 pT4; pN+: 20/38. LN short axis > 5 mm, LN enhancement, and LVD > 3 mm were significantly correlated with N+ at pathology. LVD > 3 mm had a significantly higher sensitivity and specificity (& GE;90%, AUC = 0.949) and was an independent predictor (p = 0.0016).

Vascular Enlargement as a Predictor of Nodal Involvement in Bladder Cancer / Borgheresi, Alessandra; Agostini, Andrea; Sternardi, Francesca; Cesari, Elisa; Ventura, Fiammetta; Ottaviani, Letizia; Delle Fave, Rocco Francesco; Pretore, Eugenio; Cimadamore, Alessia; Filosa, Alessandra; Galosi, Andrea Benedetto; Giovagnoni, Andrea. - In: DIAGNOSTICS. - ISSN 2075-4418. - 13:13(2023), p. 2227. [10.3390/diagnostics13132227]

Vascular Enlargement as a Predictor of Nodal Involvement in Bladder Cancer

Borgheresi, Alessandra
;
Agostini, Andrea
;
Cesari, Elisa;Ventura, Fiammetta;Ottaviani, Letizia;Delle Fave, Rocco Francesco;Pretore, Eugenio;Cimadamore, Alessia;Filosa, Alessandra;Galosi, Andrea Benedetto;Giovagnoni, Andrea
2023-01-01

Abstract

In bladder cancer (BC), the evaluation of lymph node (LN) involvement at preoperative imaging lacks specificity. Since neoangiogenesis is paired with lymphatic involvement, this study aims to evaluate the presence of perivesical venous ectasia as an indirect sign of LN involvement, together with other conventional CT findings. All the patients who underwent radical cystectomy (RC) for BC between January 2017 and December 2019 with available preoperative contrast-enhanced CT (CECT) within 1 month before surgery were included. Patients without available pathological reports (and pTNM stage) or who underwent neoadjuvant treatments and palliative RC were excluded. Two readers in blind assessed the nodal shape and hilum, the short axis, and the contrast enhancement of suspicious pelvic LNs, the Largest Venous Diameter (LVD) efferent to the lesion, and the extravesical tumor invasion. In total, 38 patients (33 males) were included: 17 pT2, 17 pT3, 4 pT4; pN+: 20/38. LN short axis > 5 mm, LN enhancement, and LVD > 3 mm were significantly correlated with N+ at pathology. LVD > 3 mm had a significantly higher sensitivity and specificity (& GE;90%, AUC = 0.949) and was an independent predictor (p = 0.0016).
2023
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/321938
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact