We evaluated the effects of salmon calcitonin (sCT) on bone callus formation. Twenty-four patients (18 women and 6 men, average age, 70 ± 8 years) with proximal femur fracture were examined. In all cases osteosynthesis was performed by Ender's nails or Kirschner's wires. Patients were divided into two age- and sex-matched groups. Group 1 was given sCT, 50 Medical Research Council Units/day for 45 days, beginning the day after surgery. Group 2 received no treatment. Roentgenographic controls were performed ten and 60 days after surgery, and roentgenograms were read blindly by a computerized method. Bone density was calculated as percent of luminance within the 1-cm area around the line of fracture. Results were expressed as the difference between the luminance values of the 60th day compared with those of the tenth day (ΔL%). ΔL% was 8.4 ± 0.56 in group 1 and 7.9 ± 0.68 in group 2 (P = 0.07). These results allow us to exclude any negative effect of sCT on bone callus formation and may suggest a favorable trend in bone repair.
Effect of salmon calcitonin on bone callus formation in man / Luisetto, G.; Melanotte, P. L.; Caira, S.; Greco, F.; Rossi, P.; Specchia, N.; Sibelli, P.; Ziliotto, D.. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - STAMPA. - 44:4(1988), pp. 572-578.
Effect of salmon calcitonin on bone callus formation in man
Greco F.;Specchia N.;
1988-01-01
Abstract
We evaluated the effects of salmon calcitonin (sCT) on bone callus formation. Twenty-four patients (18 women and 6 men, average age, 70 ± 8 years) with proximal femur fracture were examined. In all cases osteosynthesis was performed by Ender's nails or Kirschner's wires. Patients were divided into two age- and sex-matched groups. Group 1 was given sCT, 50 Medical Research Council Units/day for 45 days, beginning the day after surgery. Group 2 received no treatment. Roentgenographic controls were performed ten and 60 days after surgery, and roentgenograms were read blindly by a computerized method. Bone density was calculated as percent of luminance within the 1-cm area around the line of fracture. Results were expressed as the difference between the luminance values of the 60th day compared with those of the tenth day (ΔL%). ΔL% was 8.4 ± 0.56 in group 1 and 7.9 ± 0.68 in group 2 (P = 0.07). These results allow us to exclude any negative effect of sCT on bone callus formation and may suggest a favorable trend in bone repair.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
