Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary. Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies. In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes. In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments. Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlighted.

Cholangiocarcinoma 2020: the next horizon in mechanisms and management / Banales, J. M.; Marin, J. J. G.; Lamarca, A.; Rodrigues, P. M.; Khan, S. A.; Roberts, L. R.; Cardinale, V.; Carpino, G.; Andersen, J. B.; Braconi, C.; Calvisi, D. F.; Perugorria, M. J.; Fabris, L.; Boulter, L.; Macias, R. I. R.; Gaudio, E.; Alvaro, D.; Gradilone, S. A.; Strazzabosco, M.; Marzioni, M.; Coulouarn, C.; Fouassier, L.; Raggi, C.; Invernizzi, P.; Mertens, J. C.; Moncsek, A.; Rizvi, S.; Heimbach, J.; Koerkamp, B. G.; Bruix, J.; Forner, A.; Bridgewater, J.; Valle, J. W.; Gores, G. J.. - In: NATURE REVIEWS. GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1759-5045. - 17:9(2020), pp. 557-588. [10.1038/s41575-020-0310-z]

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Braconi C.;Alvaro D.;Marzioni M.;
2020-01-01

Abstract

Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary. Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies. In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes. In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments. Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlighted.
2020
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/295663
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 576
  • Scopus 1126
  • ???jsp.display-item.citation.isi??? 1039
social impact