A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion
Brunetti L.;
2020-01-01
Abstract
A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
