A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion / Tovy, A.; Reyes, J. M.; Gundry, M. C.; Brunetti, L.; Lee-Six, H.; Petljak, M.; Park, H. J.; Guzman, A. G.; Rosas, C.; Jeffries, A. R.; Baple, E.; Mill, J.; Crosby, A. H.; Sency, V.; Xin, B.; Machado, H. E.; Castillo, D.; Weitzel, J. N.; Li, W.; Stratton, M. R.; Campbell, P. J.; Wang, H.; Sanders, M. A.; Goodell, M. A.. - In: CELL STEM CELL. - ISSN 1934-5909. - 27:2(2020), pp. 326-335.e4. [10.1016/j.stem.2020.06.018]

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

Brunetti L.;
2020-01-01

Abstract

A human germline-mosaic for WT and DNMT3A mutant cells reveals a marked advantage for DNMT3A mutant cells in the hematopoietic system compared to epithelial cells. Deep sequencing suggests a very early tissue advantage driven by DNA methylation loss at conserved loci rather than increased mutation burden.
2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/293305
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