BRUNETTI, Lorenzo
BRUNETTI, Lorenzo
Dipartimento Scienze Cliniche e Molecolari
Actinomycin d targets npm1c-primed mitochondria to restore pml-driven senescence in aml therapy
2021-01-01 Wu, H. -C.; Rerolle, D.; Berthier, C.; Hleihel, R.; Sakamoto, T.; Quentin, S.; Benhenda, S.; Morganti, C.; Wu, C.; Conte, L.; Rimsky, S.; Sebert, M.; Clappier, E.; Souquere, S.; Gachet, S.; Soulier, J.; Durand, S.; Trowbridge, J. J.; Benit, P.; Rustin, P.; Hajj, H. E.; Raffoux, E.; Ades, L.; Itzykson, R.; Dombret, H.; Fenaux, P.; Espeli, O.; Kroemer, G.; Brunetti, L.; Mak, T. W.; Lallemand-Breitenbach, V.; Bazarbachi, A.; Falini, B.; Ito, K.; Martelli, M. P.; de The, H.
Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss
2019-01-01 Colleluori, G.; Aguirre, L.; Phadnis, U.; Fowler, K.; Armamento-Villareal, R.; Sun, Z.; Brunetti, L.; Hyoung Park, J.; Kaipparettu, B. A.; Putluri, N.; Auetumrongsawat, V.; Yarasheski, K.; Qualls, C.; Villareal, D. T.
AML-099 Prolonged XPO1 Inhibition Is Essential for Optimal Anti-Leukemic Activity in NPM1-Mutated AML
2022-01-01 Pianigiani, G.; Gagliardi, A.; Tini, V.; Bigerna, B.; Caruso, S.; Marra, A.; Shacham, S.; Landesman, Y.; Quintarelli, C.; Locatelli, F.; Martelli, M. P.; Falini, B.; Brunetti, L.
An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
2023-01-01 Mende, Hannah; Khatri, Anshu; Lange, Carolin; Poveda-Cuevas, Sergio Alejandro; Tascher, Georg; Covarrubias-Pinto, Adriana; Löhr, Frank; Koschade, Sebastian E; Dikic, Ivan; Münch, Christian; Bremm, Anja; Brunetti, Lorenzo; Brandts, Christian H; Uckelmann, Hannah; Dötsch, Volker; Rogov, Vladimir V; Bhaskara, Ramachandra M; Müller, Stefan
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells
2015-01-01 Martelli, M. P.; Gionfriddo, I.; Mezzasoma, F.; Milano, F.; Pierangeli, S.; Mulas, F.; Pacini, R.; Tabarrini, A.; Pettirossi, V.; Rossi, R.; Vetro, C.; Brunetti, L.; Sportoletti, P.; Tiacci, E.; Di Raimondo, F.; Falini, B.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
2021-01-01 Sportoletti, P.; Sorcini, D.; Guzman, A. G.; Reyes, J. M.; Stella, A.; Marra, A.; Sartori, S.; Brunetti, L.; Rossi, R.; Papa, B. D.; Adamo, F. M.; Pianigiani, G.; Betti, C.; Scialdone, A.; Guarente, V.; Spinozzi, G.; Tini, V.; Martelli, M. P.; Goodell, M. A.; Falini, B.
Blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia: A shared clonal origin
2017-01-01 Brunetti, L.; Di Battista, V.; Venanzi, A.; Schiavoni, G.; Martelli, M. P.; Ascani, S.; Mecucci, C.; Tiacci, E.; Falini, B.
Breast Cancer With Release of Tumor Cells in Peripheral Blood Mimicking Acute Myeloid Leukemia
2024-01-01 Gatti, Arianna; Brando, Bruno; Cuppari, Irene; Viola, Nadia; Brunetti, Lorenzo; Sampaolo, Michela; More, Sonia; Morichetti, Doriana; Corvatta, Laura
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression
2021-01-01 Fousek, K.; Watanabe, J.; Joseph, S. K.; George, A.; An, X.; Byrd, T. T.; Morris, J. S.; Luong, A.; Martinez-Paniagua, M. A.; Sanber, K.; Navai, S. A.; Gad, A. Z.; Salsman, V. S.; Mathew, P. R.; Kim, H. N.; Wagner, D. L.; Brunetti, L.; Jang, A.; Baker, M. L.; Varadarajan, N.; Hegde, M.; Kim, Y. -M.; Heisterkamp, N.; Abdel-Azim, H.; Ahmed, N.
CD123 is consistently expressed on NPM1-mutated AML cells
2021-01-01 Perriello, V. M.; Gionfriddo, I.; Rossi, R.; Milano, F.; Mezzasoma, F.; Marra, A.; Spinelli, O.; Rambaldi, A.; Annibali, O.; Avvisati, G.; Di Raimondo, F.; Ascani, S.; Falini, B.; Martelli, M. P.; Brunetti, L.
CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells: Correspondence
2009-01-01 Brunetti, L.; Di Noto, R.; Abate, G.; Gorrese, M.; Gravetti, A.; Raia, M.; Scalia, G.; Pascariello, C.; Camera, A.; Del Vecchio, L.
CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
2010-01-01 Martelli, M. P.; Pettirossi, V.; Thiede, C.; Bonifacio, E.; Mezzasoma, F.; Cecchini, D.; Pacini, R.; Tabarrini, A.; Ciurnelli, R.; Gionfriddo, I.; Manes, N.; Rossi, R.; Giunchi, L.; Oelschlagel, U.; Brunetti, L.; Gemei, M.; Delia, M.; Specchia, G.; Liso, A.; Di Ianni, M.; Di Raimondo, F.; Falzetti, F.; Del Vecchio, L.; Martelli, M. F.; Falini, B.
Current status and future perspectives in targeted therapy of NPM1-mutated AML
2022-01-01 Ranieri, R.; Pianigiani, G.; Sciabolacci, S.; Perriello, V. M.; Marra, A.; Cardinali, V.; Pierangeli, S.; Milano, F.; Gionfriddo, I.; Brunetti, L.; Martelli, M. P.; Falini, B.
Dactinomycin in NPM1-Mutated acute myeloid leukemia
2015-01-01 Falini, B.; Brunetti, L.; Martelli, M. P.
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML
2021-01-01 Gionfriddo, I.; Brunetti, L.; Mezzasoma, F.; Milano, F.; Cardinali, V.; Ranieri, R.; Venanzi, A.; Pierangeli, S.; Vetro, C.; Spinozzi, G.; Dorillo, E.; Wu, H. C.; Berthier, C.; Ciurnelli, R.; Griffin, M. J.; Jennings, C. E.; Tiacci, E.; Sportoletti, P.; Falzetti, F.; de The, H.; Veal, G. J.; Martelli, M. P.; Falini, B.
Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field
2021-01-01 Falini, B.; Sciabolacci, S.; Falini, L.; Brunetti, L.; Martelli, M. P.
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A
2017-01-01 Huang, Y. -H.; Su, J.; Lei, Y.; Brunetti, L.; Gundry, M. C.; Zhang, X.; Jeong, M.; Li, W.; Goodell, M. A.
DNMT3A in Leukemia
2017-01-01 Brunetti, L.; Gundry, M. C.; Goodell, M. A.
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
2023-01-01 Ramabadran, Raghav; Wang, Jarey H; Reyes, Jaime M; Guzman, Anna G; Gupta, Sinjini; Rosas, Carina; Brunetti, Lorenzo; Gundry, Michael C; Tovy, Ayala; Long, Hali; Gu, Tianpeng; Cullen, Sean M; Tyagi, Siddhartha; Rux, Danielle; Kim, Jean J; Kornblau, Steven M; Kyba, Michael; Stossi, Fabio; Rau, Rachel E; Takahashi, Koichi; Westbrook, Thomas F; Goodell, Margaret A
Effect of the COVID-19 pandemic on laboratory and clinical research: A testimony and a call to action from researchers
2020-01-01 Kabanova, A.; Gavriilaki, E.; Pelzer, B. W.; Brunetti, L.; Maiques-Diaz, A.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Actinomycin d targets npm1c-primed mitochondria to restore pml-driven senescence in aml therapy | 1-gen-2021 | Wu, H. -C.; Rerolle, D.; Berthier, C.; Hleihel, R.; Sakamoto, T.; Quentin, S.; Benhenda, S.; Morganti, C.; Wu, C.; Conte, L.; Rimsky, S.; Sebert, M.; Clappier, E.; Souquere, S.; Gachet, S.; Soulier, J.; Durand, S.; Trowbridge, J. J.; Benit, P.; Rustin, P.; Hajj, H. E.; Raffoux, E.; Ades, L.; Itzykson, R.; Dombret, H.; Fenaux, P.; Espeli, O.; Kroemer, G.; Brunetti, L.; Mak, T. W.; Lallemand-Breitenbach, V.; Bazarbachi, A.; Falini, B.; Ito, K.; Martelli, M. P.; de The, H. | |
| Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss | 1-gen-2019 | Colleluori, G.; Aguirre, L.; Phadnis, U.; Fowler, K.; Armamento-Villareal, R.; Sun, Z.; Brunetti, L.; Hyoung Park, J.; Kaipparettu, B. A.; Putluri, N.; Auetumrongsawat, V.; Yarasheski, K.; Qualls, C.; Villareal, D. T. | |
| AML-099 Prolonged XPO1 Inhibition Is Essential for Optimal Anti-Leukemic Activity in NPM1-Mutated AML | 1-gen-2022 | Pianigiani, G.; Gagliardi, A.; Tini, V.; Bigerna, B.; Caruso, S.; Marra, A.; Shacham, S.; Landesman, Y.; Quintarelli, C.; Locatelli, F.; Martelli, M. P.; Falini, B.; Brunetti, L. | |
| An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant | 1-gen-2023 | Mende, Hannah; Khatri, Anshu; Lange, Carolin; Poveda-Cuevas, Sergio Alejandro; Tascher, Georg; Covarrubias-Pinto, Adriana; Löhr, Frank; Koschade, Sebastian E; Dikic, Ivan; Münch, Christian; Bremm, Anja; Brunetti, Lorenzo; Brandts, Christian H; Uckelmann, Hannah; Dötsch, Volker; Rogov, Vladimir V; Bhaskara, Ramachandra M; Müller, Stefan | |
| Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells | 1-gen-2015 | Martelli, M. P.; Gionfriddo, I.; Mezzasoma, F.; Milano, F.; Pierangeli, S.; Mulas, F.; Pacini, R.; Tabarrini, A.; Pettirossi, V.; Rossi, R.; Vetro, C.; Brunetti, L.; Sportoletti, P.; Tiacci, E.; Di Raimondo, F.; Falini, B. | |
| Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice | 1-gen-2021 | Sportoletti, P.; Sorcini, D.; Guzman, A. G.; Reyes, J. M.; Stella, A.; Marra, A.; Sartori, S.; Brunetti, L.; Rossi, R.; Papa, B. D.; Adamo, F. M.; Pianigiani, G.; Betti, C.; Scialdone, A.; Guarente, V.; Spinozzi, G.; Tini, V.; Martelli, M. P.; Goodell, M. A.; Falini, B. | |
| Blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia: A shared clonal origin | 1-gen-2017 | Brunetti, L.; Di Battista, V.; Venanzi, A.; Schiavoni, G.; Martelli, M. P.; Ascani, S.; Mecucci, C.; Tiacci, E.; Falini, B. | |
| Breast Cancer With Release of Tumor Cells in Peripheral Blood Mimicking Acute Myeloid Leukemia | 1-gen-2024 | Gatti, Arianna; Brando, Bruno; Cuppari, Irene; Viola, Nadia; Brunetti, Lorenzo; Sampaolo, Michela; More, Sonia; Morichetti, Doriana; Corvatta, Laura | |
| CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression | 1-gen-2021 | Fousek, K.; Watanabe, J.; Joseph, S. K.; George, A.; An, X.; Byrd, T. T.; Morris, J. S.; Luong, A.; Martinez-Paniagua, M. A.; Sanber, K.; Navai, S. A.; Gad, A. Z.; Salsman, V. S.; Mathew, P. R.; Kim, H. N.; Wagner, D. L.; Brunetti, L.; Jang, A.; Baker, M. L.; Varadarajan, N.; Hegde, M.; Kim, Y. -M.; Heisterkamp, N.; Abdel-Azim, H.; Ahmed, N. | |
| CD123 is consistently expressed on NPM1-mutated AML cells | 1-gen-2021 | Perriello, V. M.; Gionfriddo, I.; Rossi, R.; Milano, F.; Mezzasoma, F.; Marra, A.; Spinelli, O.; Rambaldi, A.; Annibali, O.; Avvisati, G.; Di Raimondo, F.; Ascani, S.; Falini, B.; Martelli, M. P.; Brunetti, L. | |
| CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells: Correspondence | 1-gen-2009 | Brunetti, L.; Di Noto, R.; Abate, G.; Gorrese, M.; Gravetti, A.; Raia, M.; Scalia, G.; Pascariello, C.; Camera, A.; Del Vecchio, L. | |
| CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice | 1-gen-2010 | Martelli, M. P.; Pettirossi, V.; Thiede, C.; Bonifacio, E.; Mezzasoma, F.; Cecchini, D.; Pacini, R.; Tabarrini, A.; Ciurnelli, R.; Gionfriddo, I.; Manes, N.; Rossi, R.; Giunchi, L.; Oelschlagel, U.; Brunetti, L.; Gemei, M.; Delia, M.; Specchia, G.; Liso, A.; Di Ianni, M.; Di Raimondo, F.; Falzetti, F.; Del Vecchio, L.; Martelli, M. F.; Falini, B. | |
| Current status and future perspectives in targeted therapy of NPM1-mutated AML | 1-gen-2022 | Ranieri, R.; Pianigiani, G.; Sciabolacci, S.; Perriello, V. M.; Marra, A.; Cardinali, V.; Pierangeli, S.; Milano, F.; Gionfriddo, I.; Brunetti, L.; Martelli, M. P.; Falini, B. | |
| Dactinomycin in NPM1-Mutated acute myeloid leukemia | 1-gen-2015 | Falini, B.; Brunetti, L.; Martelli, M. P. | |
| Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML | 1-gen-2021 | Gionfriddo, I.; Brunetti, L.; Mezzasoma, F.; Milano, F.; Cardinali, V.; Ranieri, R.; Venanzi, A.; Pierangeli, S.; Vetro, C.; Spinozzi, G.; Dorillo, E.; Wu, H. C.; Berthier, C.; Ciurnelli, R.; Griffin, M. J.; Jennings, C. E.; Tiacci, E.; Sportoletti, P.; Falzetti, F.; de The, H.; Veal, G. J.; Martelli, M. P.; Falini, B. | |
| Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field | 1-gen-2021 | Falini, B.; Sciabolacci, S.; Falini, L.; Brunetti, L.; Martelli, M. P. | |
| DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A | 1-gen-2017 | Huang, Y. -H.; Su, J.; Lei, Y.; Brunetti, L.; Gundry, M. C.; Zhang, X.; Jeong, M.; Li, W.; Goodell, M. A. | |
| DNMT3A in Leukemia | 1-gen-2017 | Brunetti, L.; Gundry, M. C.; Goodell, M. A. | |
| DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells | 1-gen-2023 | Ramabadran, Raghav; Wang, Jarey H; Reyes, Jaime M; Guzman, Anna G; Gupta, Sinjini; Rosas, Carina; Brunetti, Lorenzo; Gundry, Michael C; Tovy, Ayala; Long, Hali; Gu, Tianpeng; Cullen, Sean M; Tyagi, Siddhartha; Rux, Danielle; Kim, Jean J; Kornblau, Steven M; Kyba, Michael; Stossi, Fabio; Rau, Rachel E; Takahashi, Koichi; Westbrook, Thomas F; Goodell, Margaret A | |
| Effect of the COVID-19 pandemic on laboratory and clinical research: A testimony and a call to action from researchers | 1-gen-2020 | Kabanova, A.; Gavriilaki, E.; Pelzer, B. W.; Brunetti, L.; Maiques-Diaz, A. |