Early reports described an unexpected low number of patients affected by inborn errors of immunity (IEI) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the incidence and mortality rates in IEI are still amatter of speculation. Because of the high burden ofcoronavirus disease 2019 (COVID-19) in Italy, we evaluated the impact of the pandemic on patients with IEI enrolled by 21 centers in the IPINet national registry (www.ipinet.org) withthe aim to assess SARS-CoV-2 incidence and infection-fatality rate in different IEI entities in a cohort of 3263 adult and pediatric patients for which we have the exact figure available thanks to the Italian registry for each nosological entity, to quantify the length of time of SARS-CoV-2 positivity, and to verify whether a condition of lymphopenia might be a possible predictor of COVID-19 outcome.

Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity

Danieli M. G.
Conceptualization
;
Pession A.
Conceptualization
;
Agostini C.
Conceptualization
;
Quinti I.
Conceptualization
2021

Abstract

Early reports described an unexpected low number of patients affected by inborn errors of immunity (IEI) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the incidence and mortality rates in IEI are still amatter of speculation. Because of the high burden ofcoronavirus disease 2019 (COVID-19) in Italy, we evaluated the impact of the pandemic on patients with IEI enrolled by 21 centers in the IPINet national registry (www.ipinet.org) withthe aim to assess SARS-CoV-2 incidence and infection-fatality rate in different IEI entities in a cohort of 3263 adult and pediatric patients for which we have the exact figure available thanks to the Italian registry for each nosological entity, to quantify the length of time of SARS-CoV-2 positivity, and to verify whether a condition of lymphopenia might be a possible predictor of COVID-19 outcome.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/290860
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