Erectile Dysfunction (ED) is defined as the inability to maintain and/or achieve a satisfactory erection. This condition can be influenced by the presence of atherosclerosis, a systemic pathology of the vessels that also affects the cavernous arteries and which can cause an alteration of blood flow at penile level. Among the cardiovascular risk factors affecting the genesis of atherosclerosis, hyperhomocysteinemia (HHcys) plays a central role, which is associated with oxidative stress and endothelial dysfunction. This review focuses on the biological processes that lead to homocysteine induced endothelial damage and discusses the consequences of HHcys on male sexual function.
Hyperhomocysteinemia: Focus on endothelial damage as a cause of erectile dysfunction / Salvio, G.; Ciarloni, A.; Cutini, M.; Balercia, G.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:(2021), pp. 418.1-418.9. [10.3390/ijms22010418]
Hyperhomocysteinemia: Focus on endothelial damage as a cause of erectile dysfunction
Salvio G.;Ciarloni A.;Cutini M.;Balercia G.
2021-01-01
Abstract
Erectile Dysfunction (ED) is defined as the inability to maintain and/or achieve a satisfactory erection. This condition can be influenced by the presence of atherosclerosis, a systemic pathology of the vessels that also affects the cavernous arteries and which can cause an alteration of blood flow at penile level. Among the cardiovascular risk factors affecting the genesis of atherosclerosis, hyperhomocysteinemia (HHcys) plays a central role, which is associated with oxidative stress and endothelial dysfunction. This review focuses on the biological processes that lead to homocysteine induced endothelial damage and discusses the consequences of HHcys on male sexual function.File | Dimensione | Formato | |
---|---|---|---|
35 ijms-22-00418.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza d'uso:
Creative commons
Dimensione
221.23 kB
Formato
Adobe PDF
|
221.23 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.