Neuro-cognitive deficits at school starting age may affect as many as 50% of children who underwent cardiac surgery for complex congenital heart diseases (CHD). The aim of this study was to identify which phases of cardiopulmonary bypass (CPB) are associated with an increased risk of impaired neurodevelopmental skills in children with complex CHD. This was assessed by means of glial fibrillary acidic protein (GFAP) plasma levels during CPB for CHD surgery, as a marker of neurological insult. We correlated GFAP levels with clinical parameters and neurodevelopmental outcome.
Cardiopulmonary-Bypass Glial Fibrillary Acidic Protein Correlates With Neurocognitive Skills / Vedovelli, Luca; Padalino, Massimo; Suppiej, Agnese; Sartori, Stefano; Falasco, Gianclaudio; Simonato, Manuela; Carnielli, Virgilio P; Stellin, Giovanni; Cogo, Paola. - In: ANNALS OF THORACIC SURGERY. - ISSN 0003-4975. - STAMPA. - 106:3(2018), pp. 792-798. [10.1016/j.athoracsur.2018.03.083]
Cardiopulmonary-Bypass Glial Fibrillary Acidic Protein Correlates With Neurocognitive Skills.
Carnielli, Virgilio P;
2018-01-01
Abstract
Neuro-cognitive deficits at school starting age may affect as many as 50% of children who underwent cardiac surgery for complex congenital heart diseases (CHD). The aim of this study was to identify which phases of cardiopulmonary bypass (CPB) are associated with an increased risk of impaired neurodevelopmental skills in children with complex CHD. This was assessed by means of glial fibrillary acidic protein (GFAP) plasma levels during CPB for CHD surgery, as a marker of neurological insult. We correlated GFAP levels with clinical parameters and neurodevelopmental outcome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
