Epithelial-to-mesenchymal transition (EMT) is a developmentally vital reversible process by which fully differentiated cells lose their epithelial features and acquire a migratory mesenchymal phenotype. EMT contributes to the metastatic potential of tumors. The expression profile and other biological properties of EMT suggest potential targets for cancer therapy, including in renal-cell carcinoma (RCC). The preclinical and clinical results have substantiated the promises that dysregulated elements leading to EMT can be a potential target in RCC patients. In this study, we illustrated the pathogenic and prognostic role of EMT in RCC. In addition, we reconstructed, by literature analysis, the different pathways implicated in the EMT process, thus supporting the rational for future EMT-directed therapeutic approaches for RCC patients.
Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy / Piva, Francesco; Giulietti, Matteo; Santoni, Matteo; Occhipinti, Giulia; Scarpelli, Marina; Lopez Beltran, Antonio; Cheng, Liang; Principato, Giovanni; Montironi, Rodolfo. - In: MOLECULAR DIAGNOSIS & THERAPY. - ISSN 1177-1062. - STAMPA. - 20:2(2016), pp. 111-117. [10.1007/s40291-016-0192-5]
Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy
PIVA, Francesco;GIULIETTI, MATTEO;SANTONI, MATTEO;OCCHIPINTI, GIULIA;SCARPELLI, Marina;PRINCIPATO, GIOVANNI;MONTIRONI, RODOLFO
2016-01-01
Abstract
Epithelial-to-mesenchymal transition (EMT) is a developmentally vital reversible process by which fully differentiated cells lose their epithelial features and acquire a migratory mesenchymal phenotype. EMT contributes to the metastatic potential of tumors. The expression profile and other biological properties of EMT suggest potential targets for cancer therapy, including in renal-cell carcinoma (RCC). The preclinical and clinical results have substantiated the promises that dysregulated elements leading to EMT can be a potential target in RCC patients. In this study, we illustrated the pathogenic and prognostic role of EMT in RCC. In addition, we reconstructed, by literature analysis, the different pathways implicated in the EMT process, thus supporting the rational for future EMT-directed therapeutic approaches for RCC patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
