AIMS: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. MATERIALS & METHODS: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. RESULTS: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). CONCLUSION: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.
Lgr5 expression, cancer stem cells and pancreatic cancer: Results from biological and computational analyses / Andrikou, K., Santoni, M., Piva, F., Bittoni, A., Lanese, A., Pellei, C., Conti, A., Loretelli, C., Mandolesi, A., Giulietti, M., Scarpelli, M., Principato, G., Falconi, M., Cascinu, S.. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - STAMPA. - 11:7(2015), pp. 1037-1045. [10.2217/fon.15.27]
Lgr5 expression, cancer stem cells and pancreatic cancer: Results from biological and computational analyses
ANDRIKOU, KALLIOPI;SANTONI, MATTEO;PIVA, Francesco;BITTONI, ALESSANDRO;LANESE, ANDREA;PELLEI, CHIARA;CONTI, ALESSANDRO;GIULIETTI, MATTEO;SCARPELLI, Marina;PRINCIPATO, GIOVANNI;
2015-01-01
Abstract
AIMS: To determine the relationship between Lgr5 and other stemness markers and pathologic features in pancreatic ductal adenocarcinoma (PDAC) samples. MATERIALS & METHODS: In 69 samples, Lgr5 was analyzed by qRT-PCR together with a panel of 29 genes. Bioinformatic analysis was carried out to identify a possible pathway regulating Lgr5 expression in PDAC. RESULTS: Lgr5 expression was not associated with the expression of tested cancer stem cell markers. Moreover, it was not an independent predictor of survival neither at univariate analysis (p = 0.21) nor at multivariate analysis (p = 0.225). CONCLUSION: Based on the lack of correlation between Lgr5 and tested cancer stem cell markers, Lgr5 does not seem to be a potential stemness marker or prognostic factor in PDAC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
