Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) in the hepatic cystogenesis of PCLDs.

Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases / Urribarri, Aura D; Munoz Garrido, Patricia; Perugorria, María J; Erice, Oihane; Merino Azpitarte, Maite; Arbelaiz, Ander; Lozano, Elisa; Hijona, Elizabeth; Jiménez Agüero, Raúl; Fernandez Barrena, Maite G; Jimeno, Juan P; Marzioni, Marco; Marin, Jose J. G; Masyuk, Tatyana V; Larusso, Nicholas F; Prieto, Jesús; Bujanda, Luis; Banales, Jesús M.. - In: GUT. - ISSN 0017-5749. - 63:10(2014), pp. 1658-67-1667. [10.1136/gutjnl-2013-305281]

Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases

MARZIONI, MARCO;
2014-01-01

Abstract

Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) in the hepatic cystogenesis of PCLDs.
2014
GUT
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/224830
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