Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases. Methylglyoxal exerts several biological activities. Among these it promotes advanced glycation end products (AGEs), which are crucial in pathogenesis of human disease. Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity. The aim of the study was to investigate the effect of in vitro MG-induced glycation on human high density lipoprotein (HDL) and on the activity of the enzyme paraoxonase-1 (PON1).
Glycation of human high density lipoprotein by methylglyoxal: Effect on HDL-paraoxonase activity / Bacchetti, Tiziana; Masciangelo, Simona; Armeni, Tatiana; Bicchiega, V; Ferretti, Gianna. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - STAMPA. - 63:3(2014), pp. 307-311. [10.1016/j.metabol.2013.10.013.]
Glycation of human high density lipoprotein by methylglyoxal: Effect on HDL-paraoxonase activity.
BACCHETTI, TIZIANA;MASCIANGELO, Simona;ARMENI, Tatiana;FERRETTI, GIANNA
2014-01-01
Abstract
Methylglyoxal (MG), a reactive carbonyl compound formed primarily from triose phosphates, appears to be involved in the molecular mechanisms of diabetes, end-stage renal disease and neurodegenerative diseases. Methylglyoxal exerts several biological activities. Among these it promotes advanced glycation end products (AGEs), which are crucial in pathogenesis of human disease. Previous studies have demonstrated that MG reacts with proteins and compositional modifications reflect loss of biological activity. The aim of the study was to investigate the effect of in vitro MG-induced glycation on human high density lipoprotein (HDL) and on the activity of the enzyme paraoxonase-1 (PON1).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
