The Lewis acid catalyzed (BF3·Et2O, CuCl, AcOH) one-pot three-component cyclocondensation of urea with C-glycosylated aldehydes and -keto esters (Biginelli reaction) in a combinatorial manner afforded three different series of 3,4-dihydropyrimidin- 2(1H)-ones bearing C-glycosyl moieties at C4, C6, and at both C4 and C6.
Toward the synthesis of C-glycosylated dihydropyrimidine libraries via the three-component Biginelli reaction. A novel approach to artificial nucleosides / Dondoni, A.; Massi, A.; Sabbatini, Simona. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 42:(2001), pp. 4495-4497. [10.1016/S0040-4039(01)00769-9]
Toward the synthesis of C-glycosylated dihydropyrimidine libraries via the three-component Biginelli reaction. A novel approach to artificial nucleosides.
SABBATINI, Simona
2001-01-01
Abstract
The Lewis acid catalyzed (BF3·Et2O, CuCl, AcOH) one-pot three-component cyclocondensation of urea with C-glycosylated aldehydes and -keto esters (Biginelli reaction) in a combinatorial manner afforded three different series of 3,4-dihydropyrimidin- 2(1H)-ones bearing C-glycosyl moieties at C4, C6, and at both C4 and C6.File in questo prodotto:
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