A 32-year-old man who had undergone liver transplantation for fulminant hepatitis due to HBV infection developed fatal acute necrotizing pancreatitis on the 60th post-transplant day, while showing signs of intense viral replication. Immunohistochemistry and in situ hybridization of the pancreas following autopsy showed the presence of HBsAG and HBV-DNA in the cytoplasm of acinar cells, together with the picture of necrotizing pancreatitis. Clinical and histological features seem to indicate that pancreatitis was directly caused by HBV infection.
Fatal necrotizing pancreatitis caused by HBV infection in a liver transplant recipient: clinical and histological evidence / A., Cavallari; Vivarelli, Marco; A., Derrico; R., Bellusci; P., Scarani; E., DE RAFFELE; B., Nardo; G., Gozzetti. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 22:(1995), pp. 685-690. [10.1016/0168-8278(95)80224-X]
Fatal necrotizing pancreatitis caused by HBV infection in a liver transplant recipient: clinical and histological evidence
VIVARELLI, MARCO;
1995-01-01
Abstract
A 32-year-old man who had undergone liver transplantation for fulminant hepatitis due to HBV infection developed fatal acute necrotizing pancreatitis on the 60th post-transplant day, while showing signs of intense viral replication. Immunohistochemistry and in situ hybridization of the pancreas following autopsy showed the presence of HBsAG and HBV-DNA in the cytoplasm of acinar cells, together with the picture of necrotizing pancreatitis. Clinical and histological features seem to indicate that pancreatitis was directly caused by HBV infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
