Implant-associated infections represent an occasional but serious problem in dental and/or orthopaedic surgery. A possible solution to prevent the initial bacterial adhesion may be the coating of the implant surface with a thin layer of antibiotic-loaded biocompatible polymer. Hydrogels are one of the promising and versatile materials as antibiotic controlled release systems. In this work, antibiotic-modified poly(ethylene-glycol diacrylate) hydrogel titanium coatings were prepared by electrochemical polymerization and tested against methicillin resistant Staphylococcus aureus (ATCC 33591). Two different methods to load vancomycin and ceftriaxone were used. These coating tested against methicillin resistant Staphylococcus aureus (ATCC 33591). We show that the proposed titanium coatings displayed an interesting antibacterial activity, however, further studies on their effective cytotoxicity will furnish evidence of their real clinical efficacy.
ANTIBIOTIC-MODIFIED HYDROGEL COATINGS ON TITANIUM DENTAL IMPLANTS / S., Cometa; MATTIOLI BELMONTE CIMA, Monica; D., Cafagna; R., Iatta; E., Ceci; E., De Giglio. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 26:2 Supplemento 2(2012), pp. 65 (S2)-71 (S2).
ANTIBIOTIC-MODIFIED HYDROGEL COATINGS ON TITANIUM DENTAL IMPLANTS
MATTIOLI BELMONTE CIMA, Monica;
2012-01-01
Abstract
Implant-associated infections represent an occasional but serious problem in dental and/or orthopaedic surgery. A possible solution to prevent the initial bacterial adhesion may be the coating of the implant surface with a thin layer of antibiotic-loaded biocompatible polymer. Hydrogels are one of the promising and versatile materials as antibiotic controlled release systems. In this work, antibiotic-modified poly(ethylene-glycol diacrylate) hydrogel titanium coatings were prepared by electrochemical polymerization and tested against methicillin resistant Staphylococcus aureus (ATCC 33591). Two different methods to load vancomycin and ceftriaxone were used. These coating tested against methicillin resistant Staphylococcus aureus (ATCC 33591). We show that the proposed titanium coatings displayed an interesting antibacterial activity, however, further studies on their effective cytotoxicity will furnish evidence of their real clinical efficacy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
