It has been reported that immunity to the 65 kDa heat shock protein of Mycobacterium tuberculosis (MT-hsp65) not only accompanies rheumatoid arthritis (RA), but may also be characteristic of chronic inflammation. We now report serum antibodies to MT-hsp65 in 47% of systemic sclerosis (SSc), 38% of primary Raynaud's phenomenon (PRP) and 5% of systemic lupus erythematosus (SLE). Antibody levels were higher in patients with active or progressive SSc and correlated with the degree of skin fibrosis. Thus, immunity to MT-hsp65 appears in SSc and is not limited to RA. However, it does show some degree of specificity beyond chronic inflammation: PRP patients have a higher reactivity than do SLE patients.

Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma) / Danieli, Maria Giovanna; Candela, M; Ricciatti, Am; Reginelli, R; Danieli, Giovanni; Cohen, Ir; Gabrielli, Armando. - In: JOURNAL OF AUTOIMMUNITY. - ISSN 0896-8411. - 5:4(1992), pp. 443-452.

Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).

DANIELI, Maria Giovanna;DANIELI, GIOVANNI;GABRIELLI, ARMANDO
1992-01-01

Abstract

It has been reported that immunity to the 65 kDa heat shock protein of Mycobacterium tuberculosis (MT-hsp65) not only accompanies rheumatoid arthritis (RA), but may also be characteristic of chronic inflammation. We now report serum antibodies to MT-hsp65 in 47% of systemic sclerosis (SSc), 38% of primary Raynaud's phenomenon (PRP) and 5% of systemic lupus erythematosus (SLE). Antibody levels were higher in patients with active or progressive SSc and correlated with the degree of skin fibrosis. Thus, immunity to MT-hsp65 appears in SSc and is not limited to RA. However, it does show some degree of specificity beyond chronic inflammation: PRP patients have a higher reactivity than do SLE patients.
1992
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/82126
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