It has been reported that immunity to the 65 kDa heat shock protein of Mycobacterium tuberculosis (MT-hsp65) not only accompanies rheumatoid arthritis (RA), but may also be characteristic of chronic inflammation. We now report serum antibodies to MT-hsp65 in 47% of systemic sclerosis (SSc), 38% of primary Raynaud's phenomenon (PRP) and 5% of systemic lupus erythematosus (SLE). Antibody levels were higher in patients with active or progressive SSc and correlated with the degree of skin fibrosis. Thus, immunity to MT-hsp65 appears in SSc and is not limited to RA. However, it does show some degree of specificity beyond chronic inflammation: PRP patients have a higher reactivity than do SLE patients.
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma) / Danieli, Maria Giovanna; Candela, M; Ricciatti, Am; Reginelli, R; Danieli, Giovanni; Cohen, Ir; Gabrielli, Armando. - In: JOURNAL OF AUTOIMMUNITY. - ISSN 0896-8411. - 5:4(1992), pp. 443-452.
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).
DANIELI, Maria Giovanna;DANIELI, GIOVANNI;GABRIELLI, ARMANDO
1992-01-01
Abstract
It has been reported that immunity to the 65 kDa heat shock protein of Mycobacterium tuberculosis (MT-hsp65) not only accompanies rheumatoid arthritis (RA), but may also be characteristic of chronic inflammation. We now report serum antibodies to MT-hsp65 in 47% of systemic sclerosis (SSc), 38% of primary Raynaud's phenomenon (PRP) and 5% of systemic lupus erythematosus (SLE). Antibody levels were higher in patients with active or progressive SSc and correlated with the degree of skin fibrosis. Thus, immunity to MT-hsp65 appears in SSc and is not limited to RA. However, it does show some degree of specificity beyond chronic inflammation: PRP patients have a higher reactivity than do SLE patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
