Alternative materials for autologous nerve grafts in peripheral nerve surgery have long been investigated. This report describes the use of acellular (freeze-thawed) autologous skeletal muscle grafts (ASMG) to bridge a 2 cm gap in the sciatic nerve of rats. Neurophysiologic and morphometric studies performed 6 weeks after surgical procedure showed for the nine treated Sprague-Dawley rats (Group A) a good axon regeneration rate, although this was lower than that for the control group (Group B), a lower Nerve Conduction Velocity (NCV) and a thinner myelin sheath than in group B (n = 9 Sprague-Dawley rats). In the latter case, complete resection of 2cm of the sciatic nerve was followed by an immediate coaptation of the proximal and distal ends.
The use of acellular autologous skeletal muscle grafts in peripheral nerve repair: A morphometrical-morphological study / DI BENEDETTO, GIOVANNI MARIA; F., Lassner; M., Riccio; Pugnaloni, Armanda; M. M., Tappa; G., Biagini; A., Berger; A., Bertani. - In: CLINICAL MATERIALS. - ISSN 0267-6605. - STAMPA. - 16:3(1994), pp. 137-143.
The use of acellular autologous skeletal muscle grafts in peripheral nerve repair: A morphometrical-morphological study
DI BENEDETTO, GIOVANNI MARIA;PUGNALONI, Armanda;
1994-01-01
Abstract
Alternative materials for autologous nerve grafts in peripheral nerve surgery have long been investigated. This report describes the use of acellular (freeze-thawed) autologous skeletal muscle grafts (ASMG) to bridge a 2 cm gap in the sciatic nerve of rats. Neurophysiologic and morphometric studies performed 6 weeks after surgical procedure showed for the nine treated Sprague-Dawley rats (Group A) a good axon regeneration rate, although this was lower than that for the control group (Group B), a lower Nerve Conduction Velocity (NCV) and a thinner myelin sheath than in group B (n = 9 Sprague-Dawley rats). In the latter case, complete resection of 2cm of the sciatic nerve was followed by an immediate coaptation of the proximal and distal ends.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
