ABSTRACT: Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.
Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010 / Colafigli, M.; Torti, C.; Trecarichi, E. M.; Albini, L.; Rosi, A.; Micheli, V.; Manca, N.; Penco, G.; Bruzzone, B.; Punzi, G.; Corsi, P.; Parruti, G.; Bagnarelli, Patrizia; Monno, L.; Gonnelli, A.; Cauda, R.; Di Giambenedetto, S.; On behalf of the, Arca; Ucsc, ; Brescia HIV resistance study, Groups. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1469-0691. - Article first published online: 27 APR 2012:(2012). [10.1111/j.1469-0691.2012.03847.x]
Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.
BAGNARELLI, Patrizia;
2012-01-01
Abstract
ABSTRACT: Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
