ABSTRACT: Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.
Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010 / Colafigli, M., Torti, C., Trecarichi, E.M., Albini, L., Rosi, A., Micheli, V., Manca, N., Penco, G., Bruzzone, B., Punzi, G., Corsi, P., Parruti, G., Bagnarelli, P., Monno, L., Gonnelli, A., Cauda, R., Di Giambenedetto, S., On behalf of the, A., Ucsc, ., Brescia HIV resistance study, G.. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1469-0691. - Article first published online: 27 APR 2012:(2012). [10.1111/j.1469-0691.2012.03847.x]
Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.
BAGNARELLI, Patrizia;
2012-01-01
Abstract
ABSTRACT: Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
