The ability of imipenem and meropenem in subinhibitory concentrations to influence the results of disk diffusion susceptibility tests was assessed. Selection of stably derepressed mutants resistant to beta-lactam antibiotics other than carbapenems was also investigated. Beta-lactams were shown to be subject to carbapenem-mediated antagonism in the disk diffusion test. On the other hand in vitro selection of stably derepressed mutants resistant to other beta-lactams could not be demonstrated.
Imipenem and meropenem induced resistance to beta-lactam antibiotics in Pseudomonas aeruginosa / Giacometti, Andrea; Siquini, Fm; Cirioni, Oscar; Petroni, S; Scalise, Giorgio. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - STAMPA. - 13:4(1994), pp. 315-318.
Imipenem and meropenem induced resistance to beta-lactam antibiotics in Pseudomonas aeruginosa.
GIACOMETTI, Andrea;CIRIONI, OSCAR;SCALISE, Giorgio
1994-01-01
Abstract
The ability of imipenem and meropenem in subinhibitory concentrations to influence the results of disk diffusion susceptibility tests was assessed. Selection of stably derepressed mutants resistant to beta-lactam antibiotics other than carbapenems was also investigated. Beta-lactams were shown to be subject to carbapenem-mediated antagonism in the disk diffusion test. On the other hand in vitro selection of stably derepressed mutants resistant to other beta-lactams could not be demonstrated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
