The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 microM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams.
In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa / Cirioni, Oscar; Giacometti, Andrea; Silvestri, Carmela; Della Vittoria, A; Licci, Alberto; Riva, A; Scalise, Giorgio. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 50:11(2006), pp. 3923-3925. [10.1128/AAC.00652-06]
In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa.
CIRIONI, OSCAR;GIACOMETTI, Andrea;SILVESTRI, Carmela;LICCI, ALBERTO;SCALISE, Giorgio
2006-01-01
Abstract
The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 microM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
