Botulinum toxin type A for drooling in Parkinson's disease: A double-blind, randomized, placebo-controlled study

To investigate the safety and efficacy of botulinum toxin type A (BoNTX) treatment to reduce sialorrhea in Parkinson's disease (PD), a double-blind, randomized, placebo-controlled study enrolled 32 PD patients complaining of excessive drooling. Patients received either 50 U Botox in each parotid gland or placebo without using ultrasound guidance. Subjects treated with BoNTX experienced a reduction in both drooling frequency and familial and social disability (Time X Group effect: P < 0.01), as well as in saliva production (Time X Group effect: P < 0.0001). No adverse events were recorded. BoNTX injections are safe and effective treatment for the management of PD-related drooling. (C) 2006 Movement Disorder Society.