On the basis of data suggesting the possibility of maximizing the efficacy of 5-FU by LV and IFN, a pilot clinical trial was initiated in advanced pancreatic cancer.Twenty-four patients received weekly 5-FU 600 mg/m2 bolus 1 hour after the initiation of a 2-hour infusion of 500 mg/m2 of leucovorin. Three MU of interferon alpha 2b was administered subcutaneously three times a week.Two of 22 evaluable patients obtained partial responses (8\%, confidence interval 3\%-33\%). Toxicity was severe. Diarrhea and stomatitis were the most common side effects, occurring in 50\% and 25\% of patients, respectively.Because of the presence of severe toxicity we suggest that further clinical trials in pancreatic cancer be attempted only after a better definition in preclinical studies of interactions among 5-FU, leucovorin and interferon.
5-Fluorouracil, leucovorin and interferon alpha 2b in advanced pancreatic cancer: a pilot study / Cascinu, Stefano; A., Fedeli; S. L., Fedeli; G., Catalano. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 4:(1993), pp. 83-84.
5-Fluorouracil, leucovorin and interferon alpha 2b in advanced pancreatic cancer: a pilot study.
CASCINU, Stefano;
1993-01-01
Abstract
On the basis of data suggesting the possibility of maximizing the efficacy of 5-FU by LV and IFN, a pilot clinical trial was initiated in advanced pancreatic cancer.Twenty-four patients received weekly 5-FU 600 mg/m2 bolus 1 hour after the initiation of a 2-hour infusion of 500 mg/m2 of leucovorin. Three MU of interferon alpha 2b was administered subcutaneously three times a week.Two of 22 evaluable patients obtained partial responses (8\%, confidence interval 3\%-33\%). Toxicity was severe. Diarrhea and stomatitis were the most common side effects, occurring in 50\% and 25\% of patients, respectively.Because of the presence of severe toxicity we suggest that further clinical trials in pancreatic cancer be attempted only after a better definition in preclinical studies of interactions among 5-FU, leucovorin and interferon.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
