We assessed the hypothesis that a compromised p53 function could account for the non response of colon cancer patients with low thymidylate synthase (TS) expression receiving a bolus 5-fluorouracil (5-FU) leucovorin (LV) combination.The study population consisted of 41 patients with unresectable metastatic colon cancer, homogeneously, treated with bolus 5-FU and LV.Twenty-seven patients (66\%) showed high levels of TS expression. The difference in the proportion of objective responses between patients with low (CR + PR: 7 of 14, 50\%) and high (CR + PR: 0 of 27) TS levels was statistically significant (P = 0.0001, chi-square test). p53 nuclear over-expression was found in 27 of 41 patients (66\%). No differences were observed in p53 overexpression in patients with high (66\%) or low (66\%) TS expression. p53 status was not found to be associated with response even in patients with low TS expression.p53 status measured by immunohistochemistry does not seem to be useful to identify unresponsive patients with low TS expression.
Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination / Cascinu, Stefano; V., Catalano; C., Aschele; S., Barni; D., Debernardis; L., Gallo; R., Bandelloni; M. P., Staccioli; A. M., Baldelli; A., Brenna; A., Valenti; P., Muretto; G., Catalano. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 11:(2000), pp. 1053-1056.
Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination.
CASCINU, Stefano;
2000-01-01
Abstract
We assessed the hypothesis that a compromised p53 function could account for the non response of colon cancer patients with low thymidylate synthase (TS) expression receiving a bolus 5-fluorouracil (5-FU) leucovorin (LV) combination.The study population consisted of 41 patients with unresectable metastatic colon cancer, homogeneously, treated with bolus 5-FU and LV.Twenty-seven patients (66\%) showed high levels of TS expression. The difference in the proportion of objective responses between patients with low (CR + PR: 7 of 14, 50\%) and high (CR + PR: 0 of 27) TS levels was statistically significant (P = 0.0001, chi-square test). p53 nuclear over-expression was found in 27 of 41 patients (66\%). No differences were observed in p53 overexpression in patients with high (66\%) or low (66\%) TS expression. p53 status was not found to be associated with response even in patients with low TS expression.p53 status measured by immunohistochemistry does not seem to be useful to identify unresponsive patients with low TS expression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
