Toscana virus (TOSV) infection is a frequent cause of meningitis in central Italy during summer. The disease generally has a benign course. Rarely, the infection produces a severe disease, with encephalitis and signs of systemic involvement, including lymphadenopathy. Since there is no clinical necessity of performing lymph node biopsy in such cases, the histopathological feature of TOSV-related lymphadenitis is not known. We herein present a case in which lymphadenopathy preceded the onset of meningitis. The excised lymph node showed a non-specific mixed-type lymphoid hyperplasia, with follicular hyperplasia, sinusal expansion and paracortical involvement. We also demonstrated the presence of viral protein and viral RNA in the lymph node tissue.
Histological description of the lymphadenopathy related to Toscana virus infection. Report of a case / Ranaldi, R.; Goteri, Gaia; Biagetti, Simona; Cusi, M. G.; Rossini, S.. - In: PATHOLOGY RESEARCH AND PRACTICE. - ISSN 0344-0338. - 207:3(2011), pp. 197-201. [10.1016/j.prp.2010.07.010]