OBJECTIVE: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.STUDY DESIGN: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.RESULTS: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.CONCLUSION: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal spumous cell carcinoma who may benefit from more aggressive therapy or chemoprevention. (Anal Quant Cytol Histol 2010;32:247-253)
Prognostic Significance of p53 and KAI-1 Expression in Patients with Laryngeal Squamous Cell Carcinoma / Re, Massimo; Magliulo, G.; Salvolini, Eleonora; Orciani, Monia; Gioacchini, F. M.; Goteri, Gaia; Rubini, Corrado. - In: ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY. - ISSN 0884-6812. - STAMPA. - 32:5(2010), pp. 247-253.
Prognostic Significance of p53 and KAI-1 Expression in Patients with Laryngeal Squamous Cell Carcinoma.
RE, Massimo;SALVOLINI, Eleonora;ORCIANI, Monia;GOTERI, Gaia;RUBINI, Corrado
2010-01-01
Abstract
OBJECTIVE: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.STUDY DESIGN: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.RESULTS: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.CONCLUSION: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal spumous cell carcinoma who may benefit from more aggressive therapy or chemoprevention. (Anal Quant Cytol Histol 2010;32:247-253)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
