Metal cations (Mn2+ or Ca2+) in aqueous dispersions of mixtures of dioleoylphosphatidylethanolamine (DOPE) and poly(ethylene glycol)-functionalized DOPE (DOPE-PEG(350)) induce, above a certain amount of the PEG lipid component, a phase transition from the inverted hexagonal phase HII to the bicontinuous inverted cubic phase Q224 with space group Pn3m. The process is driven by the decrease of free elastic energy due to the Gaussian curvature of the cubic phase. The structural characterization of the phase behavior over the whole explored range of DOPE-PEG/DOPE weight ratio (3−25%) is reported, focusing on the role of the metal cation in the formation of the 3D cubic lattice. This result may represent a significant progress toward a design-based approach to drug delivery.
Metal Cation Induced Cubic Phase in Poly(ethylene glycol)-Functionalized Dioleoylphosphatidylethanolamine Aqueous Dispersions / Pisani, Michela; V., Fino; P., Bruni; E., DI COLA; Francescangeli, Oriano. - In: JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL. - ISSN 1520-6106. - 112 (17):(2008), pp. 5276-5278. [10.1021/jp802211r]
Metal Cation Induced Cubic Phase in Poly(ethylene glycol)-Functionalized Dioleoylphosphatidylethanolamine Aqueous Dispersions
PISANI, MICHELA;FRANCESCANGELI, ORIANO
2008-01-01
Abstract
Metal cations (Mn2+ or Ca2+) in aqueous dispersions of mixtures of dioleoylphosphatidylethanolamine (DOPE) and poly(ethylene glycol)-functionalized DOPE (DOPE-PEG(350)) induce, above a certain amount of the PEG lipid component, a phase transition from the inverted hexagonal phase HII to the bicontinuous inverted cubic phase Q224 with space group Pn3m. The process is driven by the decrease of free elastic energy due to the Gaussian curvature of the cubic phase. The structural characterization of the phase behavior over the whole explored range of DOPE-PEG/DOPE weight ratio (3−25%) is reported, focusing on the role of the metal cation in the formation of the 3D cubic lattice. This result may represent a significant progress toward a design-based approach to drug delivery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
