A cell culture system and double fluorogenic staining were used to study the susceptibility of Cryptosporidium parvum to membrane-active antibiotics. Buforin II and magainin II exerted a cytotoxic effect on sporozoites but did not consistently affect oocyst viability. Lasalocid and nigericin demonstrated less activity against sporozoites but reduced the infectivity of oocysts.
Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture / Giacometti, Andrea; Cirioni, Oscar; Del Prete, Ms; Barchiesi, Francesco; Scalise, G.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 44:12(2000), pp. 3473-3475.
Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.
GIACOMETTI, Andrea;CIRIONI, OSCAR;BARCHIESI, FRANCESCO;
2000-01-01
Abstract
A cell culture system and double fluorogenic staining were used to study the susceptibility of Cryptosporidium parvum to membrane-active antibiotics. Buforin II and magainin II exerted a cytotoxic effect on sporozoites but did not consistently affect oocyst viability. Lasalocid and nigericin demonstrated less activity against sporozoites but reduced the infectivity of oocysts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
