Abstract Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that .90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders.

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice / Murano, I; Barbatelli, Giorgio; Parisani, V; Muzzonigro, Giovanni; Muzzonigro, G; Castellucci, Mario; Cinti, Saverio. - In: JOURNAL OF LIPID RESEARCH. - ISSN 0022-2275. - 49:(2008), pp. 1562-1568.

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

BARBATELLI, Giorgio
Methodology
;
MUZZONIGRO, GIOVANNI;CASTELLUCCI, Mario;CINTI, Saverio
2008-01-01

Abstract

Abstract Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that .90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders.
2008
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/52218
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