Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique.
Effect of Coenzyme Q(10) in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial / Tiano, Luca; Carnevali, P; Padella, L; Santoro, Lucia; Principi, F; Brugè, F; Carle, Flavia; Gesuita, Rosaria; Gabrielli, Orazio; Littarru, GIAN PAOLO. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 32:(2011), pp. 2103-2105. [10.1016/j.neurobiolaging.2009.11.016]
Effect of Coenzyme Q(10) in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial.
TIANO, LUCA;SANTORO, LUCIA;CARLE, Flavia;GESUITA, Rosaria;GABRIELLI, ORAZIO;LITTARRU, GIAN PAOLO
2011-01-01
Abstract
Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
