Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results provided insights into the puzzling issue of antistaphylococcal interactions between glycopeptides and beta-lactams, especially the paradox of double zones around beta-lactam disks and the relationships between autolysis rate and type of interaction.
Interactions between glycopeptides and ß-lactams against isogenic pairs of teicoplanin-susceptible/resistant strains of Staphylococcus haemolyticus / Vignaroli, Carla; Biavasco, Francesca; Varaldo, Pietro. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 50:(2006), pp. 2577-2582. [10.1128/AAC.00260-06]
Interactions between glycopeptides and ß-lactams against isogenic pairs of teicoplanin-susceptible/resistant strains of Staphylococcus haemolyticus.
VIGNAROLI, Carla;BIAVASCO, Francesca;VARALDO, Pietro
2006-01-01
Abstract
Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results provided insights into the puzzling issue of antistaphylococcal interactions between glycopeptides and beta-lactams, especially the paradox of double zones around beta-lactam disks and the relationships between autolysis rate and type of interaction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.