A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging.Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans.We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans / Franceschi, C; Capri, M; Monti, D; Giunta, S; Olivieri, Fabiola; Sevini, F; Panourgia, Mp; Invidia, L; Celani, L; Scurti, M; Cevenini, E; Castellani, Gc; Salvioli, S.. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - (2007).

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

OLIVIERI, Fabiola;
2007-01-01

Abstract

A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging.Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans.We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity
2007
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/40094
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