J Inorg Biochem. 2010 Aug;104(8):820-30. Epub 2010 Apr 7. Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities. Lupidi G, Marchetti F, Masciocchi N, Reger DL, Tabassum S, Astolfi P, Damiani E, Pettinari C. Source Dipartimento di Biologia Molecolare Cellulare e Animale, Università degli Studi di Camerino, Via Madonna delle carceri, I-62032 Camerino, MC, Italy. Abstract A series of Cu(II), Zn(II) and Mn(II) coordination compounds has been synthesized by reaction of the corresponding metal salts and pyrazolyl-based ligands, i.e. the neutral 1-(2-(4-((2,2,2-tri(1H-pyrazol-1-yl)ethoxy)methyl)benzyloxy)-1,1-di(1H-pyrazol-1-yl)ethyl)-1H-pyrazole {p-C(6)H(4)[CH(2)OCH(2)C(pz)(3)](2), (L(1)), and the anionic hydridotris(3-phenyl-5-methylpyrazolyl)borate (L(2))(-), bis(pyrazolyl)acetate (L(3)) and bis(3,5-dimethylpyrazolyl)acetate (L(4))(-): the species [L(1)(CuCl(2))(2)] (1), [L(1)(Cu(OAc)(2))(2)] (2), [L(1)(Zn(OAc)(2))(2)] (3), [(CuCl(L(2))(Hpz(Ph,Me))] (4), [Mn(L(3))(2)].2H(2)O, (5), [ZnCl(L(3))(imH)].MeOH [CuCl(L(4))(imH)].2H(2)O (7) have been obtained (Hpz(Ph,Me)=3-phenyl-5-methylpyrazole, imH=imidazole). Complexes 1 and 4 have been structurally characterized, also using less conventional powder diffraction methods. The superoxide scavenging activity has been characterized by indirect assays including EPR analysis. All complexes exhibit superoxide scavenging activity with IC(50) in the microM range and they protect against the oxidative action of peroxynitrite in different ways. 1, 4 and 7 exert both an anti- and pro-oxidant effect depending on their concentration as evaluated by EPR and fluorescence methods. The pro-oxidative effects are absent in Zn(II) and Mn(II) complexes. (c) 2010 Elsevier Inc. All rights reserved. PMID: 20452028 [PubMed - indexed for MEDLINE]

Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities.

ASTOLFI, PAOLA;DAMIANI, Elisabetta;
2010

Abstract

J Inorg Biochem. 2010 Aug;104(8):820-30. Epub 2010 Apr 7. Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities. Lupidi G, Marchetti F, Masciocchi N, Reger DL, Tabassum S, Astolfi P, Damiani E, Pettinari C. Source Dipartimento di Biologia Molecolare Cellulare e Animale, Università degli Studi di Camerino, Via Madonna delle carceri, I-62032 Camerino, MC, Italy. Abstract A series of Cu(II), Zn(II) and Mn(II) coordination compounds has been synthesized by reaction of the corresponding metal salts and pyrazolyl-based ligands, i.e. the neutral 1-(2-(4-((2,2,2-tri(1H-pyrazol-1-yl)ethoxy)methyl)benzyloxy)-1,1-di(1H-pyrazol-1-yl)ethyl)-1H-pyrazole {p-C(6)H(4)[CH(2)OCH(2)C(pz)(3)](2), (L(1)), and the anionic hydridotris(3-phenyl-5-methylpyrazolyl)borate (L(2))(-), bis(pyrazolyl)acetate (L(3)) and bis(3,5-dimethylpyrazolyl)acetate (L(4))(-): the species [L(1)(CuCl(2))(2)] (1), [L(1)(Cu(OAc)(2))(2)] (2), [L(1)(Zn(OAc)(2))(2)] (3), [(CuCl(L(2))(Hpz(Ph,Me))] (4), [Mn(L(3))(2)].2H(2)O, (5), [ZnCl(L(3))(imH)].MeOH [CuCl(L(4))(imH)].2H(2)O (7) have been obtained (Hpz(Ph,Me)=3-phenyl-5-methylpyrazole, imH=imidazole). Complexes 1 and 4 have been structurally characterized, also using less conventional powder diffraction methods. The superoxide scavenging activity has been characterized by indirect assays including EPR analysis. All complexes exhibit superoxide scavenging activity with IC(50) in the microM range and they protect against the oxidative action of peroxynitrite in different ways. 1, 4 and 7 exert both an anti- and pro-oxidant effect depending on their concentration as evaluated by EPR and fluorescence methods. The pro-oxidative effects are absent in Zn(II) and Mn(II) complexes. (c) 2010 Elsevier Inc. All rights reserved. PMID: 20452028 [PubMed - indexed for MEDLINE]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/38328
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