We present a SAXS-compatible microfluidic platform for studying fibrin polymerization under controlled shear. The device enables in situ monitoring of early stages of assembly while allowing precise tuning of shear conditions. SAXS measurements comparing low (10s−1) and moderate (500s−1) shear reveal reproducible differences in protofibril organization, showing that flow can influence nanoscale assembly and establishing microfluidic SAXS as a robust tool for studying dynamic, shear-sensitive protein polymerization.
How shear modulates fibrin assembly: A microfluidic SAXS perspective / Roque Diaz, Y., Ortore, M.G.. - In: NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. C, GEOPHYSICS AND SPACE PHYSICS. - ISSN 1826-9885. - 49:5-6(2026). [10.1393/ncc/i2026-26200-7]
How shear modulates fibrin assembly: A microfluidic SAXS perspective
Roque Diaz, Y.
Primo
Conceptualization
;Ortore, M. G.Ultimo
Supervision
2026-01-01
Abstract
We present a SAXS-compatible microfluidic platform for studying fibrin polymerization under controlled shear. The device enables in situ monitoring of early stages of assembly while allowing precise tuning of shear conditions. SAXS measurements comparing low (10s−1) and moderate (500s−1) shear reveal reproducible differences in protofibril organization, showing that flow can influence nanoscale assembly and establishing microfluidic SAXS as a robust tool for studying dynamic, shear-sensitive protein polymerization.| File | Dimensione | Formato | |
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