Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials / Potter, Shelley; Avery, Kerry; Ahmed, Rosina; De Boniface, Jana; Chatterjee, Sanjoy; Dodwell, David; Dubsky, Peter; Federmann, Jingjing; Finestone, Sandra; Gnant, Michael; Hlauschek, Dominik; Iwata, Hiroji; Jiang, Michael Y.; Kaidar-Person, Orit; Lee, Han-Byoel; Mackenzie, Mairead; Meyn, Anne; Poortmans, Philip; Poulakaki, Fiorita; Richardson, Andrea L.; Sepulveda, Karla A.; Spillane, Andrew J.; Thompson, Alastair M.; Werutsky, Gustavo; Wittmann, Philipp; Wright, Jean L.; Zdenkowski, Nicholas; Cowan, Katherine; Mcintosh, Stuart A.; Null, Null; Abbott, Nick; Abdah-Bortnyak, Roxolyana; Abdelwahab, Khaled; Haris, Puteri Abdul; Aebi, Stefan; Agarwal, Gaurav; Albacar, Cinta; Algara, Manuel; Aligizakis, Emmanouil; Garcia, Raphael; Amirov, Nikolay; Amreen, Saika; Ancao, María Belén; Aragón, Sofía; Arikan, Akif Enes; Aristei, Cynthia; Asif, Farah; Aznar, Marianne; Backianathan, Selvamani; Bando, Hiroko; Banys-Paluchowski, Maggie; Barrette, Vincent; Barry, Peter; Becherini, Carlotta; Berardi, Rossana; Bernstein-Molho, Rinat; Berpan, Aniwat; Beurer, Björn; Bhattacharya, Indrani; Bjelic-Radisic, Vesna; Boersma, Liesbeth; Bonci, Eduard-Alexandru; Bonetti, Andrea; Borg, Elaine; Branson, Tony; Brown-Glaberman, Ursa; Bucci, Eraldo Oreste; Bueno, Coralia; Bülbüloğlu, Güney Cem; Burnette, Brian; Cain, Henry; Campbell, Beth; Cano-Jimenez, Alicia; Ömer-Cantürk, Alp; Peterko, Ana Car; Carmichael, Amtul; Castillo, Cecilia; Chan, Nancy; Chen, Samantha; Chiu, Matthew Kin Liang; Choraria, Amit; Claros, Juncal; Collins, John; Conde-Herrero, Veronica; Constantinidou, Anastasia; Coopey, Suzanne; Copson, Ellen; Corradini, Stefanie; Corsi, Fabio; Cortes, Paulo; Crawford, Kyle; Cretella, Elisabetta; Cruz, Josefina; Cutress, Ramsey; Daiuto, Massimiliano; Daskalova, Iskra; Davies, Mark; Caluwé, Alex De; Pinta, Carolina De La; Berron, Sonia Del Barca; Delaney, Geoff P.; Deschuymer, Sarah; Micco, Rosa Di; Diaz-Gavela, Ana Aurora; Dimitrov, Dobromir; Dogan, Lutfi; Dougoud-Chauvin, Vérène; Douvetzemis, Stergios; Dragoumis, Dimitrios; Duane, Frances; Ebner, Florian; Edge, Jenny; Eiriz, Inês; Elder, Elisabeth; Elfgen, Constanze; Elsberger, Beatrix; Eraso, Arantxa; Erel, Serap; Esakia, Tamar; Espinosa-Bravo, Martin; Estevez-Diz, Maria Del Pilar; Fabiano, Veronica Yamila; Fahmy, Waleed; Fancellu, Alessandro; Fernandez, Isaura; Fernández-Morales, Luis; Ferreiro, Josefa; Fiorica, Francesco; Fougo, José; Franceschini, Gianluca; Fuentes, Hugo; Garach, Niharika; Gasparri, Maria Luisa; Generali, Daniele; Ghilli, Matteo; Gil-Gil, Miguel; Gomez, Henry Leonidas; Gössling, Gustavo; Grobmyer, Stephen; Großmann, Christoph; Gunay, Semra; Hadar, Tal; Hajjaji, Nawale; Hariharan, Nisha; Harris, Grant; Hegarty, Gemma; Heidinger, Martin; Hijal, Tarek; Hsu, Cary; Hubbard, Thomas; Huda, Farhanul; Huscher, Alessandra; Ikram, Rabia; Illarramendi, Jose Juan; Irwin, Gareth; Jagsi, Reshma; James, Melissa; Jerusalem, Guy; Jerzak, Katarzyna; Johnson, Carol; Johnson, Nathalie; Jung, Kylie; Jung, Ji-Jung; Chanthar, Vishvak; Kadayaprath, Geeta; Polat, Ayfer Kamali; Kang, Taewoo; Kanyadhara, Lohita Krishna; Çakmak, Güldeniz Karadeniz; Karakatsanis, Andreas; Karamanliev, Martin; Khan, Mah Muneer; Kihn-Alarcón, Alba; Kipps, Emma; Kirwan, Cliona; Klein, Evelyn; Ko, Hyun Soo; Konsoulova, Assia; Konstantis, Apostolos; Kontos, Michalis; Kretsi, Antigoni; Krug, David; Kunkler, Ian; Laws, Siobhan; Leal, Sara; Lee, Jeeyeon; Liang, Rhea; Valenti, Elisenda Llabres; Ludwig, Michelle; Lüftner, Diana; Luzi, Manjola; Machiels, Melanie; Macinnes, Emma; Macpherson, Iain; Madeira, Pedro; Maduro, John; Makris, George Marios; Mando, Pablo; Mansell, James; Mantilla, Willam; Maraldo, Maja; Marcou, Yiola; Margenthaler, Julie; Marta, Gustavo; Martel, Karyne; Marti, Covadonga; Martin-Quesada, Ana Isabel; Martos, Tamara; Masannat, Yazan; Masiello, Valeria; Masuda, Norikazu; Mau, Christine I.; Maulik, Shaurav; Meattini, Icro; Meduri, Bruno; Meretoja, Tuomo; Meterissian, Sarkis; Minisini, Alessandro Marco; Misra, Shagun; Montero, Angel; Morgan, Jenna; Migueláñez, Teresa Muñoz; Munzone, Elisabetta; Murawa, Dawid; Namiq, Karez; Sánchez, María Alejandra Naranjo; Narui, Kazutaka; Nguyen, Toan; Nikolic, Dejan; Nikopoulou, Angeliki; O'Neill, Conor; O'Reilly, Seamus; Oikonomou, Ira; Bagge, Roger Olofsson; Ferrando, Amparo Oltra; Papadopoulos, Lazaros; Pascual, Javier; Pasquier, David; Pellegrini, Alice; Peretz-Yablonski, Tamar; Segura, Cristina Pérez; Piñero-Madrona, Antonio; Pogoda, Katarzyna; Popescu, Razvan; Poppe, Matthew; Porpiglia, Mauro; Portik, Daniel; Moura, Jose Fernando Prado; Provenzano, Elena; Puchinskaya, Marina; Putora, Paul Martin; Radhakrishnan, Venkatraman; Rahim, Ishtiaq Ur; Ramiah, Duvern; Rao, Smitha; Ratosa, Ivica; Razis, Evangelia; Read, Rebecca; Rebaza, Lia; Redfern, Andrew; Reinert, Tomas; Retamales, Javier; Riis, Margit; Roberts, Neill; Rocco, Nicola; Rojas, Beatriz; Roshanlall, Chandeena; Rosset, Laurent; Rovera, Francesca; Rubio, Isabel T.; Russell, Nicola; Ruyssers, Natacha; Ryu, Jai Min; Sackey, Helena; Saha, Sunita; Salinas, Jorge Emilio; Sánchez-Méndez, Jose I.; Savva, Constantinos; Scardina, Lorenzo; Serra, Margherita; Setakornnukul, Jiraporn; Shanthilal, Mukesh; Sharawy, Iman; Sharma, Shelly; Shenoy, Shashank; Shetty, Preethi S.; Shoshkova, Mery; Sibbering, Mark; Sidiropoulou, Zacharoula; Silva, Aumilto; Simcock, Richard; Sirohi, Bhawana; Smith, Fiona; Snook, Kylie; De Celis, Enrique Soto Perez; Spanheimer, Philip; Stranzl, Heidi; Stuart, Kirsty; Suga, Yisihak; Susini, Tommaso; Swinden, Michael; Tandon, Megha; Tavoletta, Maria Saveria; Taylor, Donatienne; Liutti, Vitor Teixeira; Tezcanli, Evrim; Thaweerat, Wajana; Thomson, Jacqui; Thorat, Mangesh; Tsiatas, Marinos; Tsoutsou, Pelagia; Tvedskov, Tove; Ueno, Takayuki; Vaidya, Jayant; Valachis, Antonis; Berkmortel, Franchette Van Den; Hage, Jos Van Der; Duijnhoven, Frederieke Van; Van Maaren, Marissa C.; Vandermeulen, Ad; Vázquez-Barreiro, Beatriz; Velu, Umesh; Venkitaraman, Ramachandran; Vidal-Sicart, Sergi; Vohra, Lubna; Voutsadakis, Ioannis; Wadasadawala, Tabassum; Walker, Melanie; Wapnir, Irene; Warnberg, Fredrik; Wiebe, Ericka; Wong, Stephanie; Wyld, Lynda; Kumar, Sanjay; Yeh, Janice; Yiallourou, Anneza; Youn, Hyun Jo; Žatecký, Jan; Cobos, Gastón Zatta; Zeko, Amanda; Zivkovic, Marija; Zope, Anagha. - In: NPJ BREAST CANCER. - ISSN 2374-4677. - 11:1(2025). [10.1038/s41523-025-00824-w]
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials
Berardi, Rossana;
2025-01-01
Abstract
Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
